Inflammatory response of nanoparticles: mechanisms, consequences, and strategies for mitigation

M Summer, R Ashraf, S Ali, H Bach, S Noor, Q Noor… - Chemosphere, 2024 - Elsevier
Numerous nano-dimensioned materials have been generated as a result of several
advancements in nanoscale science such as metallic nanoparticles (mNPs) which have …

Role of toll-like receptors in neuroimmune diseases: Therapeutic targets and problems

H Li, S Liu, J Han, S Li, X Gao, M Wang, J Zhu… - Frontiers in …, 2021 - frontiersin.org
Toll-like receptors (TLRs) are a class of proteins playing a key role in innate and adaptive
immune responses. TLRs are involved in the development and progression of neuroimmune …

TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage

P Xu, C Tao, Y Zhu, G Wang, L Kong, W Li, R Li… - Journal of …, 2021 - Springer
Background Innate immunity can facilitate early brain injury (EBI) following subarachnoid
hemorrhage (SAH). Numerous studies suggest that pyroptosis could exacerbate …

Inflammation and anti-inflammatory targets after aneurysmal subarachnoid hemorrhage

S Muhammad, D Hänggi - International journal of molecular sciences, 2021 - mdpi.com
Aneurysmal subarachnoid hemorrhage (aSAH), with a crude worldwide incidence of around
7.9 per 100,000 person-years [1] and accounting for only 5% of all strokes, is a potentially …

Implication of M2 macrophage on NLRP3 inflammasome signaling in mediating the neuroprotective effect of Canagliflozin against methotrexate-induced cognitive …

LH Khedr, RM Rahmo, OM Eldemerdash… - International …, 2024 - Elsevier
Methotrexate (MTX), a chemotherapeutic antimetabolite, has been linked to cognitive
impairment in cancer patients. MTX-induced metabolic pathway disruption may result in …

Progress in research on TLR4-mediated inflammatory response mechanisms in brain injury after subarachnoid hemorrhage

L Wang, G Geng, T Zhu, W Chen, X Li, J Gu, E Jiang - Cells, 2022 - mdpi.com
Subarachnoid hemorrhage (SAH) is one of the common clinical neurological emergencies.
Its incidence accounts for about 5–9% of cerebral stroke patients. Even surviving patients …

From sugar binders to diabetes fighters: the lectin saga of antihyperglycemic activity through systematic review and meta-analysis

A Simha N, SM Patil, J MK, CN, LS Wong… - Frontiers in …, 2024 - frontiersin.org
Introduction Lectins are carbohydrate-binding proteins that are extremely selective for sugar
groups in the other molecules. As a result, they perform a variety of roles in biological …

ST2825, a small molecule inhibitor of MyD88, suppresses NF-κB activation and the ROS/NLRP3/cleaved caspase-1 signaling pathway to attenuate …

SS Zhang, M Liu, DN Liu, YF Shang, YH Wang, GH Du - Molecules, 2022 - mdpi.com
Neuroinflammation characterized by microglia activation is the mechanism of the occurrence
and development of various central nervous system diseases. ST2825, as a peptide-mimetic …

Achyranthes bidentata Polysaccharide Activates Nuclear Factor-Kappa B and Promotes Cytokine Production in J774A.1 Cells Through TLR4/MyD88 Signaling …

S Fan, Y Wang, Y Zhang, Y Wu, X Chen - Frontiers in Pharmacology, 2021 - frontiersin.org
Achyranthes bidentata Blume, a traditional Chinese medicine, is widely acknowledged for its
function of invigorating the liver and kidneys and as a stranguria-relieving diuretic and used …

Melatonin as a potential neuroprotectant: mechanisms in subarachnoid hemorrhage-induced early brain injury

C Xu, Z He, J Li - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Subarachnoid hemorrhage (SAH) is a common cerebrovascular disease with high mortality
and disability rates. Despite progressive advances in drugs and surgical techniques …