Mitophagy in Alzheimer's disease: Molecular defects and therapeutic approaches
Mitochondrial dysfunctions are central players in Alzheimer's disease (AD). In addition,
impairments in mitophagy, the process of selective mitochondrial degradation by autophagy …
impairments in mitophagy, the process of selective mitochondrial degradation by autophagy …
Reactive oxygen species, aging and articular cartilage homeostasis
JA Bolduc, JA Collins, RF Loeser - Free Radical Biology and Medicine, 2019 - Elsevier
Chondrocytes are responsible for the maintenance of the articular cartilage. A loss of
homeostasis in cartilage contributes to the development of osteoarthritis (OA) when the …
homeostasis in cartilage contributes to the development of osteoarthritis (OA) when the …
Mitophagy in degenerative joint diseases
K Sun, X **g, J Guo, X Yao, F Guo - Autophagy, 2021 - Taylor & Francis
Mitochondrial dysfunction is involved in aging and multiple degenerative diseases, including
intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of …
intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of …
The role of autophagy in osteoarthritis
R Duan, H **e, ZZ Liu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Chondrocytes are the only cell type in normal cartilage. The pathological changes of
osteoarthritis (OA) mostly revolve around the apoptosis and dysfunction of chondrocytes …
osteoarthritis (OA) mostly revolve around the apoptosis and dysfunction of chondrocytes …
Quercetin attenuates oxidative stress‐induced apoptosis via SIRT1/AMPK‐mediated inhibition of ER stress in rat chondrocytes and prevents the progression of …
K Feng, Z Chen, L Pengcheng… - Journal of cellular …, 2019 - Wiley Online Library
Apoptosis of chondrocytes are the main initiator of osteoarthritis (OA) and can be explained
by oxidative stress and endoplasmic reticulum (ER) stress, thus the pharmacological …
by oxidative stress and endoplasmic reticulum (ER) stress, thus the pharmacological …
[HTML][HTML] HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury
Y Zhang, D Liu, H Hu, P Zhang, R **e, W Cui - Biomedicine & …, 2019 - Elsevier
Objective The study was established to inquire into the protective effect of the HIF-1α
(Hypoxia-inducible factor-1α)/BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein) …
(Hypoxia-inducible factor-1α)/BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein) …
Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway
H Lu, C Jia, D Wu, H **, Z Lin, J Pan, X Li… - Cell Death & …, 2021 - nature.com
Osteoarthritis (OA) is a complex condition that involves both apoptosis and senescence and
currently cannot be cured. Fibroblast growth factor 21 (FGF21), known for its role as a potent …
currently cannot be cured. Fibroblast growth factor 21 (FGF21), known for its role as a potent …
Metabolic regulation of skeletal cell fate and function in physiology and disease
N Van Gastel, G Carmeliet - Nature Metabolism, 2021 - nature.com
The skeleton is diverse in its functions, which include mechanical support, movement, blood
cell production, mineral storage and endocrine regulation. This multifaceted role is achieved …
cell production, mineral storage and endocrine regulation. This multifaceted role is achieved …
Identification of Faecalibacterium prausnitzii strains for gut microbiome-based intervention in Alzheimer's-type dementia
A Ueda, S Shinkai, H Shiroma, Y Taniguchi… - Cell Reports …, 2021 - cell.com
Evidence linking the gut-brain axis to Alzheimer's disease (AD) is accumulating, but the
characteristics of causally important microbes are poorly understood. We perform a fecal …
characteristics of causally important microbes are poorly understood. We perform a fecal …
[HTML][HTML] ER stress-induced cell death in osteoarthritic cartilage
Y Rellmann, E Eidhof, R Dreier - Cellular signalling, 2021 - Elsevier
In cartilage, chondrocytes are responsible for the biogenesis and maintenance of the
extracellular matrix (ECM) composed of proteins, glycoproteins and proteoglycans. Various …
extracellular matrix (ECM) composed of proteins, glycoproteins and proteoglycans. Various …