The field of protein design has made remarkable progress over the past decade. Historically,
the low reliability of purely structure-based design methods limited their application, but …

Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

The spillovers of betacoronaviruses in humans and the emergence of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad …

Proteins are nature's primary building blocks for the construction of sophisticated molecular
machines and dynamic materials, ranging from protein complexes such as photosystem II …

Wnt proteins modulate cell proliferation and differentiation and the self-renewal of stem cells
by inducing β-catenin-dependent signalling through the Wnt receptor frizzled (FZD) and the …

HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …

The protein-folding problem was first posed about one half-century ago. The term refers to
three broad questions:(i) What is the physical code by which an amino acid sequence …

Three highly pathogenic β-coronaviruses have crossed the animal-to-human species barrier
in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2. To evaluate the …

INTRODUCTION The ultimate goal of de novo protein design is to create proteins endowed
with new biological functions. From a structural perspective, this remains a challenge …

Respiratory syncytial virus (RSV) is the leading cause of hospitalization for children under 5
years of age. We sought to engineer a viral antigen that provides greater protection than …