Autophagy-dependent ferroptosis: machinery and regulation

J Liu, F Kuang, G Kroemer, DJ Klionsky, R Kang… - Cell chemical …, 2020 - cell.com
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved cellular
process capable of degrading various biological molecules (eg, protein, glycogen, lipids …

Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective

S Kumariya, V Ubba, RK Jha, JR Gayen - Autophagy, 2021 - Taylor & Francis
Polycystic ovary syndrome (PCOS) is a unification of endocrine and metabolic disorders and
has become immensely prevalent among women of fertile age. The prime organ affected in …

A GGC-repeat expansion in ZFHX3 encoding polyglycine causes spinocerebellar ataxia type 4 and impairs autophagy

KP Figueroa, C Gross, E Buena-Atienza, S Paul… - Nature Genetics, 2024 - nature.com
Despite linkage to chromosome 16q in 1996, the mutation causing spinocerebellar ataxia
type 4 (SCA4), a late-onset sensory and cerebellar ataxia, remained unknown. Here, using …

Many roads lead to CASM: Diverse stimuli of noncanonical autophagy share a unifying molecular mechanism

J Durgan, O Florey - Science Advances, 2022 - science.org
Autophagy is a fundamental catabolic process coordinated by a network of autophagy-
related (ATG) proteins. These ATG proteins also perform an important parallel role in …

[HTML][HTML] Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease

Y Dong, H Chen, J Gao, Y Liu, J Li, J Wang - Journal of molecular and …, 2019 - Elsevier
Coronary heart disease (CHD) is a common heart disease and the leading cause of
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …

Monitoring and measuring autophagy

SR Yoshii, N Mizushima - International journal of molecular sciences, 2017 - mdpi.com
Autophagy is a cytoplasmic degradation system, which is important for starvation adaptation
and cellular quality control. Recent advances in understanding autophagy highlight its …

Exercise for osteoporosis: a literature review of pathology and mechanism

L Zhang, YL Zheng, R Wang, XQ Wang… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis (OP) is a disease that weakens bones and has a high morbidity rate
worldwide, which is prevalent among the elderly, particularly, women of postmenopausal …

A metal‐organic framework (MOF) Fenton nanoagent‐enabled nanocatalytic cancer therapy in synergy with autophagy inhibition

B Yang, L Ding, H Yao, Y Chen, J Shi - Advanced materials, 2020 - Wiley Online Library
Nanocatalytic medicine has been developed recently to trigger intratumoral generation of
highly toxic reactive oxygen species (ROS) for cancer therapy, which, unfortunately, suffers …

PGC-1α-mediated regulation of mitochondrial function and physiological implications

JF Halling, H Pilegaard - Applied Physiology, Nutrition, and …, 2020 - cdnsciencepub.com
The majority of human energy metabolism occurs in skeletal muscle mitochondria
emphasizing the importance of understanding the regulation of myocellular mitochondrial …

Guidelines for the use and interpretation of assays for monitoring autophagy

DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin… - Autophagy, 2016 - escholarship.org
Many researchers, especially those new to the field, need to determine which criteria are
essential for demonstrating autophagy, either for the purposes of their own research, or in …