Immune interferon (IFN), also known as IFN-γ, promotes not only immunomodulation but
also antimicrobial and anticancer activity. After IFN-γ binds to the complex of IFN-γ receptor …

Precise gene manipulation by gene editing approaches facilitates the potential to cure
several debilitating genetic disorders. Gene modification stimulated by engineered …

Publisher Summary This chapter focuses on the abnormal major histocompatibility complex
(MHC) expression detected in human tumors as well as on the biological role that these …

Scientific Abstract The goal of immunotherapy is to stimulate the immune system by
modification of tumor cells or expansion of lymphocytes which respond specifically to tumor …

In order to study the role of the T‐cell‐mediated immune defense in tumor development, a
total of 93 sarcomas were induced using different doses (8 μg (0.1%), 40 μg (0.5%) and 400 …

US5910488A - Plasmids suitable for gene therapy - Google Patents US5910488A - Plasmids
suitable for gene therapy - Google Patents Plasmids suitable for gene therapy Download PDF …

Class I antigens encoded in the major histocompatibility complex (MHC)(HLA in man, H-2 in
the mouse) play a key role in the recognition of target cells by cytolytic T lymphocytes. Tumor …

Publisher Summary Immunization with tumor cells or tumor extracts preventing the growth of
subsequently grafted cells provided the proof for immunogenicity of some animal tumors …

Background Many studies have suggested that the immune response may play a crucial role
in the progression of hepatocellular carcinoma (HCC). Therefore, our aim was to establish a …

Tumor cells frequently show a lack of surface Class‐I major histocompatibility complex
(MHC) antigen expression. These molecules are key recognition structures for immune …