The incidence of the metabolic syndrome has taken epidemic proportions in the past
decades, contributing to an increased risk of cardiovascular disease and diabetes. The …

Reduced glutathione (GSH) is critical for many cellular processes, and both its intracellular
and extracellular concentrations are tightly regulated. Intracellular GSH levels are regulated …

Bile acids, synthesized by hepatocytes from cholesterol, are specific and quantitatively
important organic components of bile, where they are the main driving force of the osmotic …

The human placenta plays a crucial role as the interface between mother and fetus. It
represents a unique tissue that undergoes morphological as well as functional changes on …

Studies on the increasing number of transporters found in the placental barrier are gaining
momentum, because of their tissue‐specific expression, significance in physiology and …

Numerous members of the cytochrome P450 (CYP) superfamily are induced after exposure
to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights …

The placenta is a critical organ during pregnancy, essential for the provision of an optimal
intrauterine environment, with fetal survival, growth, and development relying on correct …

The human placenta fulfills a variety of essential functions during prenatal life. Several ABC
transporters are expressed in the human placenta, where they play a role in the transport of …

Per‐and polyfluoroalkyl substances (PFAS), a class of environmental contaminants, have
been detected in human placenta and cord blood. The mechanisms driving PFAS‐induced …

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder associated
with an increased risk of adverse fetal outcomes. It is characterised by raised maternal …