Human pluripotent stem cells harbor the capacity to differentiate into cells from the three
embryonic germ layers, and this ability grants them a central role in modeling human …

Embryonic diapause is an enigmatic state of dormancy that interrupts the normally tight
connection between developmental stages and time. This reproductive strategy and state of …

Colorectal cancer (CRC) is characterized by prominent genetic and phenotypic
heterogeneity between patients. To facilitate high-throughput genetic testing and functional …

Self-renewal and differentiation of pluripotent murine embryonic stem cells (ESCs) is
regulated by extrinsic signaling pathways. It is less clear whether cellular metabolism …

Post-transcriptional mechanisms have the potential to influence complex changes in gene
expression, yet their role in cell fate transitions remains largely unexplored. Here, we show …

The gene regulatory network (GRN) of naive mouse embryonic stem cells (ESCs) must be
reconfigured to enable lineage commitment. TCF3 sanctions rewiring by suppressing …

Pluripotent stem cells have remarkable self-renewal capacity: the ability to proliferate
indefinitely while maintaining the pluripotent identity essential for their ability to differentiate …

Deciphering the mechanisms that control the pluripotent ground state is key for
understanding embryonic development. Nonetheless, the epigenetic regulation of ground …

Epigenetic mechanisms are essential to establish and safeguard cellular identities in
mammals. They dynamically regulate the expression of genes, transposable elements and …

The power of mouse embryonic stem (ES) cells to colonise the develo** embryo has
revolutionised mammalian developmental genetics and stem cell research. This power is …