Decoding the brain: From neural representations to mechanistic models

MW Mathis, AP Rotondo, EF Chang, AS Tolias… - Cell, 2024 - cell.com
A central principle in neuroscience is that neurons within the brain act in concert to produce
perception, cognition, and adaptive behavior. Neurons are organized into specialized brain …

A neuronal least-action principle for real-time learning in cortical circuits

W Senn, D Dold, AF Kungl, B Ellenberger, J Jordan… - ELife, 2024 - elifesciences.org
One of the most fundamental laws of physics is the principle of least action. Motivated by its
predictive power, we introduce a neuronal least-action principle for cortical processing of …

Predicting proprioceptive cortical anatomy and neural coding with topographic autoencoders

M Grogan, KP Blum, Y Wu, JA Harston… - PLoS computational …, 2024 - journals.plos.org
Proprioception is one of the least understood senses, yet fundamental for the control of
movement. Even basic questions of how limb pose is represented in the somatosensory …

Neuro-musculoskeletal modeling reveals muscle-level neural dynamics of adaptive learning in sensorimotor cortex

T DeWolf, S Schneider, P Soubiran, A Roggenbach… - bioRxiv, 2024 - biorxiv.org
The neural activity of the brain is intimately coupled to the dynamics of the body. Yet how our
hierarchical sensorimotor system dynamically orchestrates the generation of movement …

Proprioceptive engagement of the human cerebellum studied with 7T-fMRI

EJP Brouwer, N Priovoulos, J Hashimoto… - Imaging …, 2024 - direct.mit.edu
Proprioception, the process of perceiving our bodies in space, is a key aspect of self-
perception. The cerebellar cortex is believed to play a critical role in proprioception …

Artificial intelligence meets body sense: task-driven neural networks reveal computational principles of the proprioceptive pathway

LE van Dyck, F Bremmer, K Dobs - Signal Transduction and Targeted …, 2024 - nature.com
In a recent study published in Cell, Marin Vargas and Bisi et al. 1 present an innovative
approach to unravel the computational principles underlying proprioceptive processing in …

Modeling Sensorimotor Processing with Physics-Informed Neural Networks

A Perez Rotondo, A Marin Vargas, M Dimitriou… - bioRxiv, 2024 - biorxiv.org
Proprioception is essential for planning and executing precise movements. Muscle spindles,
the key mechanoreceptors for proprioception, are the principle sensory neurons enabling …

Internal Dynamics Interact with Proprioceptive Feedback During Movement Execution in an RNN Model of Motor Cortex

H Jiang, X Bu, Z Zheng, X Pan, Y Chen - bioRxiv, 2023 - biorxiv.org
Neuronal population responses in motor cortex display low-dimensional rotational patterns,
where neural state rotates consistently during movement execution. These patterns are …

Modeling proprioception with task-driven neural network models

H Scherberger - Neuron, 2024 - Elsevier
In a recent issue of Cell, Vargas and colleagues 1 demonstrate that task-driven neural
network models are superior at predicting proprioceptive activity in the primate cuneate …

NeuroAI for AI Safety

P Mineault, N Zanichelli, JZ Peng, A Arkhipov… - arxiv preprint arxiv …, 2024 - arxiv.org
As AI systems become increasingly powerful, the need for safe AI has become more
pressing. Humans are an attractive model for AI safety: as the only known agents capable of …