Spatial omics: Navigating to the golden era of cancer research
The idea that tumour microenvironment (TME) is organised in a spatial manner will not
surprise many cancer biologists; however, systematically capturing spatial architecture of …
surprise many cancer biologists; however, systematically capturing spatial architecture of …
[HTML][HTML] A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells
Tumor-infiltrating myeloid cells (TIMs) are key regulators in tumor progression, but the
similarity and distinction of their fundamental properties across different tumors remain …
similarity and distinction of their fundamental properties across different tumors remain …
Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer
Anti-PD-1 treatment has shown unprecedented clinical success in the treatment of non-small-
cell lung cancer (NSCLC), but the underlying mechanisms remain incompletely understood …
cell lung cancer (NSCLC), but the underlying mechanisms remain incompletely understood …
Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance
Tumor-infiltrating T cells offer a promising avenue for cancer treatment, yet their states
remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …
remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …
Single-cell meta-analyses reveal responses of tumor-reactive CXCL13+ T cells to immune-checkpoint blockade
Immune-checkpoint blockade (ICB) therapies represent a paradigm shift in the treatment of
human cancers; however, it remains incompletely understood how tumor-reactive T cells …
human cancers; however, it remains incompletely understood how tumor-reactive T cells …
Immune phenotypic linkage between colorectal cancer and liver metastasis
Y Liu, Q Zhang, B **ng, N Luo, R Gao, K Yu, X Hu, Z Bu… - Cancer cell, 2022 - cell.com
The tumor microenvironment (TME) is connected to immunotherapy responses, but it
remains unclear how cancer cells and host tissues differentially influence the immune …
remains unclear how cancer cells and host tissues differentially influence the immune …
A pan-cancer single-cell panorama of human natural killer cells
F Tang, J Li, L Qi, D Liu, Y Bo, S Qin, Y Miao, K Yu… - Cell, 2023 - cell.com
Natural killer (NK) cells play indispensable roles in innate immune responses against tumor
progression. To depict their phenotypic and functional diversities in the tumor …
progression. To depict their phenotypic and functional diversities in the tumor …
scGNN is a novel graph neural network framework for single-cell RNA-Seq analyses
Single-cell RNA-sequencing (scRNA-Seq) is widely used to reveal the heterogeneity and
dynamics of tissues, organisms, and complex diseases, but its analyses still suffer from …
dynamics of tissues, organisms, and complex diseases, but its analyses still suffer from …
Exploring the heterogeneous targets of metabolic aging at single-cell resolution
Our limited understanding of metabolic aging poses major challenges to comprehending the
diverse cellular alterations that contribute to age-related decline, and to devising targeted …
diverse cellular alterations that contribute to age-related decline, and to devising targeted …
[HTML][HTML] Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation
Y Gao, J Li, W Cheng, T Diao, H Liu, Y Bo, C Liu… - Cancer Cell, 2024 - cell.com
Fibroblasts, known for their functional diversity, play crucial roles in inflammation and
cancer. In this study, we conduct comprehensive single-cell RNA sequencing analyses on …
cancer. In this study, we conduct comprehensive single-cell RNA sequencing analyses on …