Biophysical principles of ion-channel-mediated mechanosensory transduction

CD Cox, N Bavi, B Martinac - Cell reports, 2019 - cell.com
Recent rapid progress in the field of mechanobiology has been driven by novel emerging
tools and methodologies and growing interest from different scientific disciplines. Specific …

[HTML][HTML] The ion channels to cytoskeleton connection as potential mechanism of mechanosensitivity

B Martinac - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2014 - Elsevier
As biological force-sensing systems mechanosensitive (MS) ion channels present the best
example of coupling molecular dynamics of membrane proteins to the mechanics of the …

NompC TRP channel is essential for Drosophila sound receptor function

T Effertz, R Wiek, MC Göpfert - Current Biology, 2011 - cell.com
The idea that the NompC TRPN1 channel is the Drosophila transducer for hearing has been
challenged by remnant sound-evoked nerve potentials in nompC nulls [1–5]. We now report …

Hearing in insects

MC Göpfert, RM Hennig - Annual Review of Entomology, 2016 - annualreviews.org
Insect hearing has independently evolved multiple times in the context of intraspecific
communication and predator detection by transforming proprioceptive organs into ears …

Elasticity of individual protocadherin 15 molecules implicates tip links as the gating springs for hearing

TF Bartsch, FE Hengel, A Oswald… - Proceedings of the …, 2019 - National Acad Sciences
Hair cells, the sensory receptors of the inner ear, respond to mechanical forces originating
from sounds and accelerations. An essential feature of each hair cell is an array of …

Mechanical systems biology of C. elegans touch sensation

M Krieg, AR Dunn, MB Goodman - BioEssays, 2015 - Wiley Online Library
The sense of touch informs us of the physical properties of our surroundings and is a critical
aspect of communication. Before touches are perceived, mechanical signals are transmitted …

Bacterial mechanosensitive channels: models for studying mechanosensory transduction

B Martinac, T Nomura, G Chi, E Petrov… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Sensations of touch and hearing are manifestations of mechanical contact and
air pressure acting on touch receptors and hair cells of the inner ear, respectively. In …

Neuronal stretch reception–Making sense of the mechanosense

R Das, S Wieser, M Krieg - Experimental Cell Research, 2019 - Elsevier
The sensation of mechanical force underlies many of our daily activities. As the sense of
touch determines the quality of life, the subconscious sense of proprioception and visceral …

Using light-sheet microscopy to study spontaneous activity in the develo** lateral-line system

Q Zhang, KS Kindt - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Hair cells are the sensory receptors in the auditory and vestibular systems of all vertebrates,
and in the lateral-line system of aquatic vertebrates. The purpose of this work is to explore …

Pairwise coupling of hair cell transducer channels links auditory sensitivity and dynamic range

SM van Netten, CJW Meulenberg, GWT Lennan… - … -European Journal of …, 2009 - Springer
Hair cells in the inner ear provide the basis for the exquisite hearing capabilities of
mammals. These cells transduce sound-induced displacements of their mechanosensitive …