Protease allergens as initiators–regulators of allergic inflammation

WT Soh, J Zhang, MD Hollenberg, H Vliagoftis… - Allergy, 2023 - Wiley Online Library
Tremendous progress in the last few years has been made to explain how seemingly
harmless environmental proteins from different origins can induce potent Th2‐biased …

Epithelial barrier repair and prevention of allergy

E Goleva, E Berdyshev, DYM Leung - The Journal of clinical investigation, 2019 - jci.org
Allergic diseases have in common a dysfunctional epithelial barrier, which allows the
penetration of allergens and microbes, leading to the release of type 2 cytokines that drive …

[HTML][HTML] An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission

J Ding, JJ Garber, A Uchida, A Lefkovith… - Nature …, 2024 - nature.com
Coordinated cell interactions within the esophagus maintain homeostasis, and disruption
can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly …

Detergent exposure induces epithelial barrier dysfunction and eosinophilic inflammation in the esophagus

AD Doyle, MY Masuda, GC Pyon, H Luo, A Putikova… - Allergy, 2023 - Wiley Online Library
Abstract Background Eosinophilic esophagitis (EoE) is a chronic allergic disease associated
with type 2 inflammation and epithelial barrier dysfunction. The etiology is unknown …

Clonally expanded, GPR15-expressing pathogenic effector TH2 cells are associated with eosinophilic esophagitis

DM Morgan, B Ruiter, NP Smith, AA Tu, B Monian… - Science …, 2021 - science.org
Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the recruitment of
eosinophils to the esophagus, resulting in chronic inflammation. We sought to understand …

Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation

M Rochman, T Wen, M Kotliar, PJ Dexheimer… - JCI …, 2022 - pmc.ncbi.nlm.nih.gov
Inflammation of the esophageal epithelium is a hallmark of eosinophilic esophagitis (EoE),
an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells …

Pathophysiology of non-IgE-mediated food allergy

S Zhang, S Sicherer, MC Berin… - ImmunoTargets and …, 2021 - Taylor & Francis
Non-IgE-mediated food allergies are a group of disorders characterized by subacute or
chronic inflammatory processes in the gut. Unlike IgE mediated food allergies that may result …

Eosinophilic esophagitis: Immune mechanisms and therapeutic targets

D Khokhar, S Marella, G Idelman… - Clinical & …, 2022 - Wiley Online Library
Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease of the
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …

[HTML][HTML] Mechanistic insights into the antipruritic effects of lebrikizumab, an anti–IL-13 mAb

Y Miron, PE Miller, C Hughes, T Indersmitten… - Journal of Allergy and …, 2022 - Elsevier
Background Atopic dermatitis (AD) is a chronic, inflammatory skin disease with persistent
and severe itch among its hallmark features. Significant increases in type 2 cytokines (ie, IL …

Allergic comorbidity in eosinophilic esophagitis: mechanistic relevance and clinical implications

P Capucilli, DA Hill - Clinical reviews in allergy & immunology, 2019 - Springer
Allergic eosinophilic esophagitis (EoE) is a chronic, allergen-mediated inflammatory disease
of the esophagus, and the most common cause of prolonged dysphagia in children and …