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Protease allergens as initiators–regulators of allergic inflammation
Tremendous progress in the last few years has been made to explain how seemingly
harmless environmental proteins from different origins can induce potent Th2‐biased …
harmless environmental proteins from different origins can induce potent Th2‐biased …
Epithelial barrier repair and prevention of allergy
E Goleva, E Berdyshev, DYM Leung - The Journal of clinical investigation, 2019 - jci.org
Allergic diseases have in common a dysfunctional epithelial barrier, which allows the
penetration of allergens and microbes, leading to the release of type 2 cytokines that drive …
penetration of allergens and microbes, leading to the release of type 2 cytokines that drive …
[HTML][HTML] An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission
Coordinated cell interactions within the esophagus maintain homeostasis, and disruption
can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly …
can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly …
Detergent exposure induces epithelial barrier dysfunction and eosinophilic inflammation in the esophagus
Abstract Background Eosinophilic esophagitis (EoE) is a chronic allergic disease associated
with type 2 inflammation and epithelial barrier dysfunction. The etiology is unknown …
with type 2 inflammation and epithelial barrier dysfunction. The etiology is unknown …
Clonally expanded, GPR15-expressing pathogenic effector TH2 cells are associated with eosinophilic esophagitis
DM Morgan, B Ruiter, NP Smith, AA Tu, B Monian… - Science …, 2021 - science.org
Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the recruitment of
eosinophils to the esophagus, resulting in chronic inflammation. We sought to understand …
eosinophils to the esophagus, resulting in chronic inflammation. We sought to understand …
Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation
Inflammation of the esophageal epithelium is a hallmark of eosinophilic esophagitis (EoE),
an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells …
an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells …
Pathophysiology of non-IgE-mediated food allergy
S Zhang, S Sicherer, MC Berin… - ImmunoTargets and …, 2021 - Taylor & Francis
Non-IgE-mediated food allergies are a group of disorders characterized by subacute or
chronic inflammatory processes in the gut. Unlike IgE mediated food allergies that may result …
chronic inflammatory processes in the gut. Unlike IgE mediated food allergies that may result …
Eosinophilic esophagitis: Immune mechanisms and therapeutic targets
D Khokhar, S Marella, G Idelman… - Clinical & …, 2022 - Wiley Online Library
Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease of the
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …
[HTML][HTML] Mechanistic insights into the antipruritic effects of lebrikizumab, an anti–IL-13 mAb
Y Miron, PE Miller, C Hughes, T Indersmitten… - Journal of Allergy and …, 2022 - Elsevier
Background Atopic dermatitis (AD) is a chronic, inflammatory skin disease with persistent
and severe itch among its hallmark features. Significant increases in type 2 cytokines (ie, IL …
and severe itch among its hallmark features. Significant increases in type 2 cytokines (ie, IL …
Allergic comorbidity in eosinophilic esophagitis: mechanistic relevance and clinical implications
P Capucilli, DA Hill - Clinical reviews in allergy & immunology, 2019 - Springer
Allergic eosinophilic esophagitis (EoE) is a chronic, allergen-mediated inflammatory disease
of the esophagus, and the most common cause of prolonged dysphagia in children and …
of the esophagus, and the most common cause of prolonged dysphagia in children and …