As yet, there is no cure for metastatic breast cancer. Historically, considerable research effort
has been concentrated on understanding the processes of metastasis, how a primary …

Until recently most studies of metastasis only measured the end point of the process—
macroscopic metastases. Although these studies have provided much useful information …

This 2004 volume in the World Health Organization series on histologic and genetic ty**
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

Imaging of collectively invading cocultures of carcinoma cells and stromal fibroblasts reveals
that the leading cell is always a fibroblast and that carcinoma cells move within tracks in the …

Introduction Invasive lobular carcinoma (ILC) comprises approximately 10% of breast
cancers and appears to have a distinct biology. Because it is less common than infiltrating …

Bone metastasis occurs at≈ 70% frequency in metastatic breast cancer. The mechanisms
used by tumors to hijack the skeleton, promote bone metastases, and confer therapeutic …

Collective cell migration occurs in a range of contexts: cancer cells frequently invade in
cohorts while retaining cell–cell junctions. Here we show that collective invasion by cancer …

The clinical outcomes and therapeutic strategies for infiltrating ductal carcinoma (IDC) and
infiltrating lobular carcinoma (ILC) are not uniform. The primary objectives of this study were …

Bone is an active organ that continuously undergoes an orchestrated process of remodeling
throughout life. Bone tissue is uniquely capable of adapting to loading, hormonal, and other …

BACKGROUND The clinicopathologic features of infiltrating lobular carcinoma (ILC), which
represents 5% to 15% of all breast cancers, are still controversial. In particular, the high …