Early mast cell (MC) infiltration has been reported in a wide range of human and animal
tumors particularly malignant melanoma and breast and colorectal cancer. The …

The critical role of angiogenesis in promoting tumor growth and metastasis is strongly
established. However, tumors show considerable variation in angiogenic characteristics and …

Mast cells are unique tissue-resident immune cells of the myeloid lineage that have long
been implicated in the pathogenesis of allergic and autoimmune disorders. More recently …

Gastric cancer is diagnosed in nearly one million new patients each year and it remains the
second leading cause of cancer-related deaths worldwide. Although gastric cancer …

Mast cells are haematopoietic cells that arise from pluripotent precursors of the bone
marrow. They play immunomodulatory roles in both health and disease. When appropriately …

The process of angiogenesis is well described for its potential role in the development of
normal ovaries, and physiological functions as well as in the initiation, progression, and …

An association between mast cells and tumor angiogenesis is known to exist, but the exact
role that mast cells play in this process is still unclear. It is thought that the mediators …

Liver cancer represents a substantial global health challenge, contributing significantly to
worldwide morbidity and mortality. It has long been understood that tumors are not …

The breast cancer tumor microenvironment (TME) is dynamic, with various immune and non-
immune cells interacting to regulate tumor progression and anti-tumor immunity. It is now …

Human mast cells (MCs) are a rich reservoir of neutral proteases, packed in large amounts
in their granules and comprising a high fraction of all cellular proteins. Among these …