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Exploring the dynamic interplay between cancer stem cells and the tumor microenvironment: implications for novel therapeutic strategies
Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …
The PI3K-Akt-mTOR signaling pathway in human acute myeloid leukemia (AML) cells
I Nepstad, KJ Hatfield, IS Grønningsæter… - International journal of …, 2020 - mdpi.com
Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by
uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Malignant cell …
uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Malignant cell …
Metabolic requirements for the maintenance of self-renewing stem cells
A distinctive feature of stem cells is their capacity to self-renew to maintain pluripotency.
Studies of genetically-engineered mouse models and recent advances in metabolomic …
Studies of genetically-engineered mouse models and recent advances in metabolomic …
[HTML][HTML] Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells
Developmental fate decisions are dictated by master transcription factors (TFs) that interact
with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors …
with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors …
Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents
Acute myeloid leukemia (AML) is driven by leukemia stem cells (LSCs) that resist
conventional chemotherapy and are the major cause of relapse,. Hypomethylating agents …
conventional chemotherapy and are the major cause of relapse,. Hypomethylating agents …
[HTML][HTML] Curcumin: An age-old anti-inflammatory and anti-neoplastic agent
Curcumin is a natural anti-inflammatory agent that has been used for treating medical
conditions for many years. Several experimental and pharmacologic trials have …
conditions for many years. Several experimental and pharmacologic trials have …
Cancer stem cells: impact, heterogeneity, and uncertainty
The differentiation of tumorigenic cancer stem cells into nontumorigenic cancer cells confers
heterogeneity to some cancers beyond that explained by clonal evolution or environmental …
heterogeneity to some cancers beyond that explained by clonal evolution or environmental …
RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax
Cancer driver mutations often show distinct temporal acquisition patterns, but the biological
basis for this, if any, remains unknown. RAS mutations occur invariably late in the course of …
basis for this, if any, remains unknown. RAS mutations occur invariably late in the course of …
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
Acute myeloid leukemia (AML) is organized as a cellular hierarchy initiated and maintained
by a subset of self-renewing leukemia stem cells (LSC). We hypothesized that increased …
by a subset of self-renewing leukemia stem cells (LSC). We hypothesized that increased …
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
Colon cancer is one of the best-understood neoplasms from a genetic perspective,,, yet it
remains the second most common cause of cancer-related death, indicating that some of its …
remains the second most common cause of cancer-related death, indicating that some of its …