In the CNS, iron in several proteins is involved in many important processes such as oxygen
transportation, oxidative phosphorylation, myelin production, and the synthesis and …

The blood–brain barrier (BBB) is a barrier that separates the blood from the brain tissue and
possesses unique characteristics that make the delivery of drugs to the brain a great …

Iron dysregulation has been implicated in multiple neurodegenerative diseases, including
Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain …

Single-cell transcriptomics provide a systematic map of gene expression in different human
cell types. The next challenge is to systematically understand cell-type-specific gene …

There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in
neurons. Neuromelanin accumulates during aging and is the catecholamine-derived …

Iron is an essential element for numerous fundamental biologic processes, but excess iron is
toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney …

Iron is an essential trace metal for almost all organisms, including human; however,
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …

Aims: The pathophysiological role of iron in Parkinson's disease (PD) was assessed by a
chelation strategy aimed at reducing oxidative damage associated with regional iron …

This is the fifth in the series of reviews developed as part of the Biomarkers of Nutrition for
Development (BOND) program. The BOND Iron Expert Panel (I-EP) reviewed the extant …

Iron is an essential trace element in the human body, but excess iron is toxic as it contributes
to oxidative damage. To keep iron concentration within the optimal physiologic range, iron …