Identification of protein–protein interactions (PPIs) is at the center of molecular biology
considering the unquestionable role of proteins in cells. Combinatorial interactions result in …

Identification of drug-like small molecules that alter protein–protein interactions might be a
key step in drug discovery. However, it is very challenging to find such molecules that target …

Skp2 E3 ligase is overexpressed in numerous human cancers and plays a critical role in cell-
cycle progression, senescence, metabolism, cancer progression, and metastasis. In the …

Summary The Toll/interleukin-1 receptor (TIR) domain occurs in animal and plant immune
receptors. In the animal Toll-like receptors, homodimerization of the intracellular TIR domain …

The ability of proteins to establish highly selective interactions with a variety of (macro)
molecular partners is a crucial prerequisite to the realization of their biological functions. The …

Prediction of protein-protein interactions at the structural level on the proteome scale is
important because it allows prediction of protein function, helps drug discovery and takes …

Ras proteins recruit and activate effectors, including Raf, that transmit receptor-initiated
signals. Monomeric Ras can bind Raf; however, activation of Raf requires its dimerization. It …

Hot spots constitute a small fraction of protein–protein interface residues, yet they account
for a large fraction of the binding affinity. Based on our previous method (KFC), we present …

Protein–protein interactions (PPIs) are vital to all biological processes. These interactions
are often dynamic, sometimes transient, typically occur over large topographically shallow …

Large contact surfaces of protein–protein interactions (PPIs) remain to be an ongoing issue
in the discovery and design of small molecule modulators. Peptides are intrinsically capable …