Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains
AR Todeschini, S Hakomori - Biochimica et Biophysica Acta (BBA)-General …, 2008 - Elsevier
At cell surface microdomains, glycosyl epitopes, carried either by glycosphingolipids, N-or O-
linked oligosaccharides, are recognized by carbohydrate-binding proteins or …
linked oligosaccharides, are recognized by carbohydrate-binding proteins or …
[HTML][HTML] Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motility
S Hakomori - FEBS letters, 2010 - Elsevier
Glycosphingolipids NeuAcα3Galβ4Glcβ1Cer (GM3) and GalNAcβ4 [NeuAcα3]
Galβ4Glcβ1Cer (GM2) inhibit (i) cell growth through inhibition of tyrosine kinase associated …
Galβ4Glcβ1Cer (GM2) inhibit (i) cell growth through inhibition of tyrosine kinase associated …
Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor
SJ Yoon, K Nakayama, T Hikita… - Proceedings of the …, 2006 - National Acad Sciences
Epidermal growth factor receptor (EGFR) at membrane microdomains plays an essential
role in the growth control of epidermal cells, including cancer cells derived therefrom. Ligand …
role in the growth control of epidermal cells, including cancer cells derived therefrom. Ligand …
Flexible macromolecules attached to lipid bilayers: impact on fluidity, curvature, permeability and stability of the membranes
C Tribet, F Vial - Soft Matter, 2008 - pubs.rsc.org
This review summarizes recent investigations on the association of macromolecules on lipid
bilayers. Hydrophilic and flexible polymers can form soft coronae tenuously adsorbed or …
bilayers. Hydrophilic and flexible polymers can form soft coronae tenuously adsorbed or …
Carbohydrate to carbohydrate interaction in development process and cancer progression
K Handa, S Hakomori - Glycoconjugate journal, 2012 - Springer
Two types of carbohydrate to carbohydrate interaction (CCI) have been known to be
involved in biological processes. One is the CCI between molecules expressed on …
involved in biological processes. One is the CCI between molecules expressed on …
Changes of glycoconjugate expression profiles during early development
K Handa, S Hakomori - Glycoconjugate Journal, 2017 - Springer
A variety of glycoconjugates, including glycosphingolipids (GSLs), expressed in mammalian
tissues and cells were isolated and characterized in early biochemical studies. Later studies …
tissues and cells were isolated and characterized in early biochemical studies. Later studies …
Equilibrium-fluctuation-analysis of single liposome binding events reveals how cholesterol and Ca2+ modulate glycosphingolipid trans-interactions
Carbohydrate− carbohydrate interactions (CCIs) are of central importance for several
biological processes. However, the ultra-weak nature of CCIs generates difficulties in …
biological processes. However, the ultra-weak nature of CCIs generates difficulties in …
Weak carbohydrate–carbohydrate interactions in membrane adhesion are fuzzy and generic
Carbohydrates such as the trisaccharide motif LeX are key constituents of cell surfaces.
Despite intense research, the interactions between carbohydrates of apposing cells or …
Despite intense research, the interactions between carbohydrates of apposing cells or …
Interaction of N-linked glycans, having multivalent GlcNAc termini, with GM3 ganglioside
SJ Yoon, K Nakayama, N Takahashi, H Yagi… - Glycoconjugate …, 2006 - Springer
GM3 ganglioside interacts specifically with complex-type N-linked glycans having
multivalent GlcNAc termini, as shown for (1) and (2) below.(1) Oligosaccharides (OS) …
multivalent GlcNAc termini, as shown for (1) and (2) below.(1) Oligosaccharides (OS) …
Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion
Glycolipids mediate stable membrane adhesion of potential biological relevance. In this
article, we investigate the trans-and cis-interactions of glycolipids in molecular dynamics …
article, we investigate the trans-and cis-interactions of glycolipids in molecular dynamics …