Paracetamol (acetaminophen) is the most commonly used over‐the‐counter (OTC) drug in
the world. Despite its popularity and use for many years, the safety of its application and its …

The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

The therapeutic potential of cannabinoids has been the topic of extensive investigation
following the discovery of cannabinoid receptors and their endogenous ligands …

Endocannabinoids are lipid chemical mediators that act locally by activating cannabinoid
receptors of type 1 (CB 1) and type 2 (CB 2) receptors. The two most-studied …

Neuropathic pain is a debilitating form of chronic pain resulting from nerve injury, disease
states, or toxic insults. Neuropathic pain is often refractory to conventional …

Endocannabinoids are released following brain injury and may protect against excitotoxic
damage during the acute stage of injury. Brain injury also activates microglia in a secondary …

Acetaminophen (APAP) continues to be one of the most popular analgesics available in the
United States despite that the mechanisms of antinociception elicited by APAP are not yet …

The endocannabinoids are lipid-derived messengers that play a diversity of regulatory roles
in mammalian physiology. Dysfunctions in their activity have been implicated in various …

Background and Purpose Cannabichromene (CBC) is one of the most abundant
phytocannabinoids in Cannabis spp. It has modest antinociceptive and anti‐inflammatory …

The endocannabinoid system is up-regulated in numerous pathophysiological states such
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …