CaMKII: a central molecular organizer of synaptic plasticity, learning and memory
Abstract Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most
abundant protein in excitatory synapses and is central to synaptic plasticity, learning and …
abundant protein in excitatory synapses and is central to synaptic plasticity, learning and …
Spine dynamics in the brain, mental disorders and artificial neural networks
In the brain, most synapses are formed on minute protrusions known as dendritic spines.
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …
Meta-reinforcement learning via orbitofrontal cortex
The meta-reinforcement learning (meta-RL) framework, which involves RL over multiple
timescales, has been successful in training deep RL models that generalize to new …
timescales, has been successful in training deep RL models that generalize to new …
CaM kinase: still inspiring at 40
KU Bayer, H Schulman - Neuron, 2019 - cell.com
Summary The Ca 2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) was touted as
a memory molecule, even before its involvement in long-term potentiation (LTP) was shown …
a memory molecule, even before its involvement in long-term potentiation (LTP) was shown …
Synaptic memory and CaMKII
RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …
were discovered within a decade of each other and have been inextricably intertwined ever …
NMDA receptor functions in health and disease: Old actor, new dimensions
N-Methyl-D-aspartate ionotropic glutamate receptors (NMDARs) play key roles in
synaptogenesis, synaptic maturation, long-term plasticity, neuronal network activity, and …
synaptogenesis, synaptic maturation, long-term plasticity, neuronal network activity, and …
CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation
Transient information input to the brain leads to persistent changes in synaptic circuits,
contributing to the formation of memory engrams. Pre-and postsynaptic structures undergo …
contributing to the formation of memory engrams. Pre-and postsynaptic structures undergo …
Molecular mechanism of hippocampal long-term potentiation–Towards multiscale understanding of learning and memory
Y Hayashi - Neuroscience Research, 2022 - Elsevier
Long-term potentiation (LTP) of synaptic transmission is considered to be a cellular
counterpart of learning and memory. Activation of postsynaptic NMDA type glutamate …
counterpart of learning and memory. Activation of postsynaptic NMDA type glutamate …
TIAM1-mediated synaptic plasticity underlies comorbid depression–like and ketamine antidepressant–like actions in chronic pain
Chronic pain often leads to depression, increasing patient suffering and worsening
prognosis. While hyperactivity of the anterior cingulate cortex (ACC) appears to be critically …
prognosis. While hyperactivity of the anterior cingulate cortex (ACC) appears to be critically …
A revised view of the role of CaMKII in learning and memory
Abstract The Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) plays a
fundamental role in learning and possibly also in memory. However, current mechanistic …
fundamental role in learning and possibly also in memory. However, current mechanistic …