T-cell quality in memory and protection: implications for vaccine design
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter
flow cytometry has allowed a simultaneous assessment of the phenotype and multiple …
flow cytometry has allowed a simultaneous assessment of the phenotype and multiple …
Heterologous prime–boost vaccination
S Lu - Current opinion in immunology, 2009 - Elsevier
An effective vaccine usually requires more than one time immunization in the form of prime–
boost. Traditionally the same vaccines are given multiple times as homologous boosts. New …
boost. Traditionally the same vaccines are given multiple times as homologous boosts. New …
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction
Aerobic glycolysis regulates T cell function. However, whether and how primary cancer
alters T cell glycolytic metabolism and affects tumor immunity in cancer patients remains a …
alters T cell glycolytic metabolism and affects tumor immunity in cancer patients remains a …
Dominant TNF-α+Mycobacterium tuberculosis–specific CD4+ T cell responses discriminate between latent infection and active disease
Rapid diagnosis of active Mycobacterium tuberculosis (Mtb) infection remains a clinical and
laboratory challenge. We have analyzed the cytokine profile (interferon-γ (IFN-γ), tumor …
laboratory challenge. We have analyzed the cytokine profile (interferon-γ (IFN-γ), tumor …
Viruses as vaccine vectors for infectious diseases and cancer
Recent developments in the use of viruses as vaccine vectors have been facilitated by a
better understanding of viral biology. Advances occur as we gain greater insight into the …
better understanding of viral biology. Advances occur as we gain greater insight into the …
Technologies for enhanced efficacy of DNA vaccines
F Saade, N Petrovsky - Expert review of vaccines, 2012 - Taylor & Francis
Despite many years of research, human DNA vaccines have yet to fulfill their early promise.
Over the past 15 years, multiple generations of DNA vaccines have been developed and …
Over the past 15 years, multiple generations of DNA vaccines have been developed and …
The evolution of poxvirus vaccines
After Edward Jenner established human vaccination over 200 years ago, attenuated
poxviruses became key players to contain the deadliest virus of its own family: Variola virus …
poxviruses became key players to contain the deadliest virus of its own family: Variola virus …
Challenges in the development of an HIV-1 vaccine
DH Barouch - Nature, 2008 - nature.com
The development of a safe and effective human immunodeficiency virus (HIV)-1 vaccine is a
critically important global health priority. Despite recent advances in our understanding of …
critically important global health priority. Despite recent advances in our understanding of …
High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival
Chronic infections induce T cells showing impaired cytokine secretion and up-regulated
expression of inhibitory receptors such as PD-1. What determines the acquisition of this …
expression of inhibitory receptors such as PD-1. What determines the acquisition of this …
The role of antibodies in HIV vaccines
Licensed vaccines against viral diseases generate antibodies that neutralize the infecting
virus and protect against infection or disease. Similarly, an effective vaccine against HIV-1 …
virus and protect against infection or disease. Similarly, an effective vaccine against HIV-1 …