Mitochondria reside at the crossroads of catabolic and anabolic metabolism—the essence of
life. How their structure and function are dynamically tuned in response to tissue-specific …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …

Nicotinamide adenine dinucleotide (NAD+) is a central metabolite involved in energy and
redox homeostasis as well as in DNA repair and protein deacetylation reactions …

Summary NAD (H) and NADP (H) have traditionally been viewed as co-factors (or co-
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …

Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD+) levels are
hallmarks of skeletal muscle ageing and sarcopenia,–, but it is unclear whether these …

Mitochondrial diseases are some of the most common inherited neurometabolic disorders,
and major progress has been made in our understanding, diagnosis, and treatment of these …

Nicotinamide riboside is a precursor to the important cofactor nicotinamide adenine
dinucleotide and has elicited metabolic benefits in multiple preclinical studies. In 2016, the …

Depletion of nicotinamide adenine dinucleotide (NAD+), a central redox cofactor and the
substrate of key metabolic enzymes, is the causative factor of a number of inherited and …