T cells are crucial players in adaptive anti-cancer immunity. The gene modification of T cells
with tumor antigen-specific T cell receptors (TCRs) was a milestone in personalized cancer …

Antigen immunogenicity and the specificity of binding of T-cell receptors to antigens are key
properties underlying effective immune responses. Here we propose diffRBM, an approach …

Tumor-specific T cells (TSTs) are essential components for the success of personalized
tumor-infiltrating lymphocyte (TIL)-based adoptive cellular therapy (ACT). Therefore, the …

Tumor-specific CD8+ T cells are critical components of antitumor immunity; however, factors
that modulate their phenotype and function have not been completely elucidated. Cytokines …

Adoptive cell therapy with tumor-infiltrating lymphocytes (TIL) can mediate tumor regression,
including complete and durable responses, in a range of solid cancers, most notably in …

The ecto-ATPase CD39 is expressed on exhausted CD8+ T cells in chronic viral infection
and has been proposed as a marker of tumor-specific CD8+ T cells in cancer, but the role of …

The Wilms' tumor protein 1 (WT1) is a well-known and prioritized tumor-associated antigen
expressed in numerous solid and blood tumors. Its abundance and immunogenicity have …

Sjögren's disease (SjD) is a chronic autoimmune disease characterized by focal lymphocytic
inflammation in lacrimal and salivary glands. We recently identified IL-27 as a requisite …

Lung cancer remains the most prevalent malignant tumor worldwide and is the leading
cause of cancer‐related mortality. Although immune checkpoint blockade has revolutionized …

The molecular mechanisms underlying epitope recognition by T cell receptors (TCRs) are
critical for activating T cell immune responses and rationally designing TCR-based …