The genetic and environmental factors for keratoconus

A Gordon-Shaag, M Millodot… - BioMed research …, 2015 - Wiley Online Library
Keratoconus (KC) is the most common cornea ectatic disorder. It is characterized by a cone‐
shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment. It …

Keratoconus: an inflammatory disorder?

V Galvis, T Sherwin, A Tello, J Merayo, R Barrera… - Eye, 2015 - nature.com
Keratoconus has been classically defined as a progressive, non-inflammatory condition,
which produces a thinning and steepening of the cornea. Its pathophysiological …

The correlation between keratoconus and eye rubbing: a review

H Najmi, Y Mobarki, K Mania… - International journal …, 2019 - pmc.ncbi.nlm.nih.gov
Keratoconus is a non-inflammatory disorder which is gradual in development; corneal
thinning and ectatic protrusion characterizes it. Keratoconus prevalence varies between …

Pediatric keratoconus: a review of the literature

S Mukhtar, BK Ambati - International ophthalmology, 2018 - Springer
Purpose To describe the epidemiology and prevalence, rates of progression, difference
between adult and pediatric populations, and therapeutic approaches to pediatric …

Eye rubbing in the aetiology of keratoconus: a systematic review and meta-analysis

S Sahebjada, HH Al-Mahrouqi, S Moshegov… - Graefe's Archive for …, 2021 - Springer
Purpose Keratoconus is a potentially blinding condition that slowly deforms the cornea in
young people. Despite the increasing prevalence of keratoconus, the exact aetiology of the …

Keratoconus

RB Singh, S Koh, N Sharma, FA Woreta… - Nature Reviews …, 2024 - nature.com
Keratoconus is a progressive eye disorder primarily affecting individuals in adolescence and
early adulthood. The ectatic changes in the cornea cause thinning and cone-like steepening …

[HTML][HTML] Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A

R Shetty, A Ghosh, RR Lim… - … & visual science, 2015 - tvst.arvojournals.org
Purpose.: The present study was designed to understand the role of inflammatory cytokines
secreted by corneal epithelial cells in keratoconus (KC) and the response to treatment with …

Cytokine expression in keratoconus and its corneal microenvironment: a systematic review

RPL Wisse, JJW Kuiper, R Gans, S Imhof… - The ocular …, 2015 - Elsevier
Keratoconus (KC) is a progressive corneal ecstasia characterized by thinning and
weakening of the cornea that leads to a cone-like appearance, scarring, and decreased …

Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus

YS Rabinowitz, V Galvis, A Tello, D Rueda… - Experimental eye …, 2021 - Elsevier
Both genetic and environmental factors have been considered to play a role in the etiology
keratoconus. Eye rubbing, and more recently eye compression due to slee** position …

Cell therapy in the cornea: The emerging role of microenvironment

G Suanno, VG Genna, E Maurizi, AA Dieh… - Progress in Retinal and …, 2024 - Elsevier
The cornea is an ideal testing field for cell therapies. Its highly ordered structure, where
specific cell populations are sequestered in different layers, together with its accessibility …