IgE and IgG antibodies as regulators of mast cell and basophil functions in food allergy
Food allergy is a major health issue, affecting the lives of 8% of US children and their
families. There is an urgent need to identify the environmental and endogenous signals that …
families. There is an urgent need to identify the environmental and endogenous signals that …
Food allergy
H Renz, KJ Allen, SH Sicherer, HA Sampson… - Nature reviews Disease …, 2018 - nature.com
Food allergies manifest in a variety of clinical conditions within the gastrointestinal tract, skin
and lungs, with the most dramatic and sometimes fatal manifestation being anaphylactic …
and lungs, with the most dramatic and sometimes fatal manifestation being anaphylactic …
Landscape of mast cell populations across organs in mice and humans
M Tauber, L Basso, J Martin, L Bostan… - Journal of Experimental …, 2023 - rupress.org
Mast cells (MCs) are tissue-resident immune cells that exhibit homeostatic and neuron-
associated functions. Here, we combined whole-tissue imaging and single-cell RNA …
associated functions. Here, we combined whole-tissue imaging and single-cell RNA …
Mast cell function: a new vision of an old cell
Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …
effectors of allergy. It has been only in the past two decades that mast cells have gained …
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of
the airway, including asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP) …
the airway, including asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP) …
Innate and adaptive type 2 immunity in lung allergic inflammation
M Kubo - Immunological reviews, 2017 - Wiley Online Library
Allergic inflammation is a type 2 immune disorder classically characterized by high levels of
immunoglobulin E (IgE) and the development of Th2 cells. Asthma is a pulmonary allergic …
immunoglobulin E (IgE) and the development of Th2 cells. Asthma is a pulmonary allergic …
Regulatory T cell-derived TGF-β1 controls multiple checkpoints governing allergy and autoimmunity
The mechanisms by which regulatory T (Treg) cells differentially control allergic and
autoimmune responses remain unclear. We show that Treg cells in food allergy (FA) had …
autoimmune responses remain unclear. We show that Treg cells in food allergy (FA) had …
[HTML][HTML] Food allergies: the basics
R Valenta, H Hochwallner, B Linhart, S Pahr - Gastroenterology, 2015 - Elsevier
IgE-associated food allergy affects approximately 3% of the population and has severe
effects on the daily life of patients—manifestations occur not only in the gastrointestinal tract …
effects on the daily life of patients—manifestations occur not only in the gastrointestinal tract …
[HTML][HTML] Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy
Oral immunotherapy has had limited success in establishing tolerance in food allergy,
reflecting failure to elicit an effective regulatory T (Treg) cell response. We show that disease …
reflecting failure to elicit an effective regulatory T (Treg) cell response. We show that disease …
Mechanical skin injury promotes food anaphylaxis by driving intestinal mast cell expansion
Mast cell (MC) mediator release after crosslinking of surface-bound IgE antibody by ingested
antigen underlies food allergy. However, IgE antibodies are not uniformly associated with …
antigen underlies food allergy. However, IgE antibodies are not uniformly associated with …