Targeting Cdc20 as a novel cancer therapeutic strategy
Abstract The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …
MicroRNAs as therapeutic targets in chemoresistance
M Garofalo, CM Croce - Drug resistance updates, 2013 - Elsevier
Despite substantial progress in understanding the cancer signaling network, effective
therapies remain scarce due to insufficient disruption of oncogenic pathways, drug …
therapies remain scarce due to insufficient disruption of oncogenic pathways, drug …
Genetic determinants of outcome in intrahepatic cholangiocarcinoma
Background and Aim Genetic alterations in intrahepatic cholangiocarcinoma (iCCA) are
increasingly well characterized, but their impact on outcome and prognosis remains …
increasingly well characterized, but their impact on outcome and prognosis remains …
[HTML][HTML] Cell cycle regulation of human DNA repair and chromatin remodeling genes
Maintenance of a genome requires DNA repair integrated with chromatin remodeling. We
have analyzed six transcriptome data sets and one data set on translational regulation of …
have analyzed six transcriptome data sets and one data set on translational regulation of …
Cdc20 and securin overexpression predict short-term breast cancer survival
H Karra, H Repo, I Ahonen, E Löyttyniemi… - British journal of …, 2014 - nature.com
Background: Cdc20 is an essential component of cell division and responsible for anaphase
initiation regulated by securin degradation. Cdc20 function is strongly regulated by the …
initiation regulated by securin degradation. Cdc20 function is strongly regulated by the …
miR-494 promotes cell proliferation, migration and invasion, and increased sorafenib resistance in hepatocellular carcinoma by targeting PTEN Retraction in/10.3892 …
K Liu, S Liu, W Zhang, B Jia, L Tan… - Oncology …, 2015 - spandidos-publications.com
Abstract MicroRNA-494 (miR-494) acts as an oncomiR and is involved in tumor
development, progression and metastasis, and confers resistance to chemotherapeutic …
development, progression and metastasis, and confers resistance to chemotherapeutic …
Cdc20: a potential novel therapeutic target for cancer treatment
Z Wang, L Wan, J Zhong, H Inuzuka… - Current …, 2013 - ingentaconnect.com
The Anaphase Promoting Complex (APC) has been characterized to play pivotal roles in
regulating the timely cell cycle progression by forming two functionally distinct E3 ubiquitin …
regulating the timely cell cycle progression by forming two functionally distinct E3 ubiquitin …
MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1
MN Zhan, XT Yu, J Tang, CX Zhou, CL Wang… - Cell death & …, 2018 - nature.com
MicroRNA (miRNA) is involved in the progression and metastasis of diverse human cancers,
including breast cancer, as strong evidence has been found that miRNAs can act as …
including breast cancer, as strong evidence has been found that miRNAs can act as …
miRNA-based therapeutic strategies
M Ishida, FM Selaru - Current Pathobiology Reports, 2013 - Springer
Micro-RNAs (miRNAs) are short, non-coding RNA species, thought to act primarily through
downregulation of target mRNA species with subsequent decrease in encoded proteins …
downregulation of target mRNA species with subsequent decrease in encoded proteins …
[HTML][HTML] miR‑494 is an independent prognostic factor and promotes cell migration and invasion in colorectal cancer by directly targeting PTEN
HB Sun, X Chen, H Ji, T Wu… - International …, 2014 - spandidos-publications.com
Accumulating evidence has shown that microRNAs (miRNAs) are involved in multiple
processes in cancer development and progression. Upregulation of miRNA‑494 (miR‑494) …
processes in cancer development and progression. Upregulation of miRNA‑494 (miR‑494) …