Leishmanial mechanisms of virulence have been proposed previously to involve two
different groups of parasite molecules. One group consists of largely surface and secretory …

Regulatory T cells are critical in regulating the immune response, and therefore play an
important role in the defense against infection and control of autoimmune diseases …

Leishmaniasis, that affects millions of people worldwide, is an infectious disease caused by
the protozoan parasite Leishmania. Incidence of the condition appears to be increasing in …

Regulatory T cells play a major role in modulating the immune response. However, most
information on these cells centers on autoimmunity, and there is also considerable …

The functional division of CD4+ T cells into Th1 and Th2 subsets is generally accepted but
the mechanisms leading to their preferential induction remain elusive. Cytokines are …

The acquisition of immunity following subclinical or resolved infection with the intracellular
parasite Leishmania donovani suggests that vaccination could prevent visceral …

Development of an effective vaccine against Leishmania infection is a priority of tropical
disease research. We have recently demonstrated protection against Leishmania major in …

Visceral leishmaniasis is the most severe form of leishmaniasis. To date, there is no effective
vaccine against this disease. Many antigens have been examined so far as protein-or DNA …

Immunity to Trypanosoma cruzi requires elicitation of humoral and cell-mediated immune
responses to extracellular trypomastigotes and intracellular amastigotes. In this study, the …

We have recently shown that a cocktail containing two leishmanial recombinant antigens
(LmSTI1 and TSA) and interleukin-12 (IL-12) as an adjuvant induces solid protection in both …