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Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology
Alzheimer disease is the most prevalent form of dementia globally and is characterized
premortem by a gradual memory loss and deterioration of higher cognitive functions and …
premortem by a gradual memory loss and deterioration of higher cognitive functions and …
Friend or foe? Defining the role of glutamate in aging and Alzheimer's disease
Aging is a naturally occurring decline of physiological processes and biological pathways
that affects both the structural and functional integrity of the body and brain. These …
that affects both the structural and functional integrity of the body and brain. These …
Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls
Human Alzheimer's disease (AD) brains and transgenic AD mouse models manifest
hyperexcitability. This aberrant electrical activity is caused by synaptic dysfunction that …
hyperexcitability. This aberrant electrical activity is caused by synaptic dysfunction that …
Synaptic dysfunction in Alzheimer's disease: the effects of amyloid beta on synaptic vesicle dynamics as a novel target for therapeutic intervention
The most prevalent form of dementia in the elderly is Alzheimer's disease. A significant
contributing factor to the progression of the disease appears to be the progressive …
contributing factor to the progression of the disease appears to be the progressive …
Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease
K Takahashi, JB Foster, CLG Lin - Cellular and Molecular Life Sciences, 2015 - Springer
Glutamate is the predominant excitatory neurotransmitter in the central nervous system.
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …
Amyloid beta-related alterations to glutamate signaling dynamics during Alzheimer's disease progression
Alzheimer's disease (AD) ranks sixth on the Centers for Disease Control and Prevention Top
10 Leading Causes of Death list for 2016, and the Alzheimer's Association attributes 60% to …
10 Leading Causes of Death list for 2016, and the Alzheimer's Association attributes 60% to …
Super-resolution microscopy: a closer look at synaptic dysfunction in Alzheimer disease
The synapse has emerged as a critical neuronal structure in the degenerative process of
Alzheimer disease (AD), in which the pathogenic signals of two key players—amyloid-β (Aβ) …
Alzheimer disease (AD), in which the pathogenic signals of two key players—amyloid-β (Aβ) …
[HTML][HTML] Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability
MC De Wilde, CR Overk, JW Sijben, E Masliah - Alzheimer's & dementia, 2016 - Elsevier
Introduction Loss of synapses best correlates to cognitive deficits in Alzheimer's disease
(AD) in which oligomeric neurotoxic species of amyloid-β appears to contribute synaptic …
(AD) in which oligomeric neurotoxic species of amyloid-β appears to contribute synaptic …
Human brain-derived Aβ oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP
Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's
disease (AD) and several theories have been advanced to explain the relationship. A …
disease (AD) and several theories have been advanced to explain the relationship. A …
Sex differences in psychiatric disease: a focus on the glutamate system
Alterations in glutamate, the primary excitatory neurotransmitter in the brain, are implicated
in several psychiatric diseases. Many of these psychiatric diseases display epidemiological …
in several psychiatric diseases. Many of these psychiatric diseases display epidemiological …