Overlap** genes in natural and engineered genomes
Modern genome-scale methods that identify new genes, such as proteogenomics and
ribosome profiling, have revealed, to the surprise of many, that overlap in genes, open …
ribosome profiling, have revealed, to the surprise of many, that overlap in genes, open …
Stability, robustness, and containment: preparing synthetic biology for real-world deployment
Highlights•Environmentally responsive survival circuitry enable synthetic cell containment.•
Increased genetic stability by engineering sequence and host context.•Control circuits for …
Increased genetic stability by engineering sequence and host context.•Control circuits for …
Fighting the battle against evolution: designing genetically modified organisms for evolutionary stability
M Arbel-Groissman, I Menuhin-Gruman, D Naki… - Trends in …, 2023 - cell.com
Synthetic biology has made significant progress in many areas, but a major challenge that
has received limited attention is the evolutionary stability of synthetic constructs made of …
has received limited attention is the evolutionary stability of synthetic constructs made of …
The design and engineering of synthetic genomes
Synthetic genomics seeks to design and construct entire genomes to mechanistically dissect
fundamental questions of genome function and to engineer organisms for diverse …
fundamental questions of genome function and to engineer organisms for diverse …
Prolonging genetic circuit stability through adaptive evolution of overlap** genes
The development of synthetic biological circuits that maintain functionality over application-
relevant time scales remains a significant challenge. Here, we employed synthetic …
relevant time scales remains a significant challenge. Here, we employed synthetic …
Intestinal engineered probiotics as living therapeutics: chassis selection, colonization enhancement, gene circuit design, and biocontainment
Intestinal probiotics are often used for the in situ treatment of diseases, such as metabolic
disorders, tumors, and chronic inflammatory infections. Recently, there has been an …
disorders, tumors, and chronic inflammatory infections. Recently, there has been an …
Metabolic engineering for large‐scale environmental bioremediation
Designing biological agents for counteracting the noxious effects of chemical pollutants
includes–but goes beyond–engineering biodegradative pathways in suitable microbial …
includes–but goes beyond–engineering biodegradative pathways in suitable microbial …
GENTANGLE: integrated computational design of gene entanglements
The design of two overlap** genes in a microbial genome is an emerging technique for
adding more reliable control mechanisms in engineered organisms for increased stability …
adding more reliable control mechanisms in engineered organisms for increased stability …
GENTANGLE: integrated computational design of gene entanglements
The design of two overlap** genes in a microbial genome is an emerging technique for
adding more reliable control mechanisms in engineered organisms for increased stability …
adding more reliable control mechanisms in engineered organisms for increased stability …
Creating overlap** genes by alternate-frame insertion
Overlap** genes, wherein two different proteins are translated from alternative frames of
the same DNA sequence, provide a means to stabilize an engineered gene by directly …
the same DNA sequence, provide a means to stabilize an engineered gene by directly …