Crystallography supplies unparalleled detail on structural information critical for mechanistic
analyses; however, it is restricted to describing low energy conformations of …

Complement in mammalian plasma recognizes pathogenic, immunogenic and apoptotic cell
surfaces, promotes inflammatory responses and marks particles for cell lysis, phagocytosis …

Flexibility between domains of proteins is often critical for function. These motions and
proteins with large scale flexibility in general are often not readily amenable to conventional …

Factor H (FH) regulates the activation of C3b in the alternative complement pathway, both in
serum and at host cell surfaces. It is composed of 20 short complement regulator (SCR) …

The complement system plays crucial roles in a wide breadth of immune and inflammatory
processes and is frequently cited as an etiological or aggravating factor in many human …

Atypical hemolytic uremic syndrome (aHUS) is a disease of hemolytic anemia,
thrombocytopenia, and renal failure associated with defective alternative pathway (AP) …

The anionic polysaccharides heparin and heparan sulphate play essential roles in the
regulation of many physiological processes. Heparin is often used as an analogue for …

Factor H (FH) is the major plasma regulator of the central complement protein C3b in the
alternative pathway of complement activation. The elucidation of the FH interactions with five …

Human complement receptor type 2 (CR2/CD21) is a B lymphocyte membrane glycoprotein
that plays a central role in the immune responses to foreign Ags as well as the development …

In previous studies, we showed that the pathogenic fungus Cryptococcus neoformans (Cn)
produces a specific and unique protein called antiphagocytic protein 1 (App1), which inhibits …