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A comprehensive overview of dry powder inhalers for pulmonary drug delivery: Challenges, advances, optimization techniques, and applications
Dry powder inhaler (DPI) is an attractive dosage form for local and systemic pulmonary drug
delivery. However, designing DPIs with adequate physicochemical properties is …
delivery. However, designing DPIs with adequate physicochemical properties is …
Searching for physiologically relevant in vitro dissolution techniques for orally inhaled drugs
Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …
formulations for systemic treatment have been developed. For efficient development of …
Utilization of supercritical CO2 gas antisolvent (GAS) for production of Capecitabine nanoparticles as anti-cancer drug: Analysis and optimization of the process …
Reducing the size of pharmaceutical particles is an approved way to enhance solubility and
bioavailability of a drug, leading to a decrease in the drug dose and its side effects. In this …
bioavailability of a drug, leading to a decrease in the drug dose and its side effects. In this …
Preparation and evaluation of tacrolimus-loaded thermosensitive solid lipid nanoparticles for improved dermal distribution
Background: Tacrolimus (TCR), also known as FK-506, is a biopharmaceutics classification
system (BCS) class II drug that is insoluble in water because of its high log P values. After …
system (BCS) class II drug that is insoluble in water because of its high log P values. After …
Supercritical antisolvent coprecipitation mechanisms
Supercritical antisolvent precipitation (SAS) has been successfully used to produce
microparticles and nanoparticles of controlled size and distribution either as a single …
microparticles and nanoparticles of controlled size and distribution either as a single …
Preparation of orodispersible tablets of bosentan using xylitol and menthol as dissolution enhancers
Bosentan is a drug used to treat pulmonary hypertension via dual endothelial receptor
antagonism. Bosentan has a restricted oral bioavailability, a problem that's mostly due to …
antagonism. Bosentan has a restricted oral bioavailability, a problem that's mostly due to …
Overcoming multidrug resistance through inhalable siRNA nanoparticles-decorated porous microparticles based on supercritical fluid technology
Background In recent times, the co-delivery therapeutics have garnered enormous interest
from researchers in the treatment of cancers with multidrug resistance (MDR) due to their …
from researchers in the treatment of cancers with multidrug resistance (MDR) due to their …
[HTML][HTML] Advancements in the design and development of dry powder inhalers and potential implications for generic development
Dry powder inhalers (DPIs) are drug–device combination products where the complexity of
the formulation, its interaction with the device, and input from users play important roles in …
the formulation, its interaction with the device, and input from users play important roles in …
Preparation and characterization of sustained release pirfenidone loaded microparticles for pulmonary drug delivery: Spray drying approach
Pirfenidone (PFD) is a drug of choice for the treatment of idiopathic pulmonary fibrosis. For
the preparation of sustained release microparticles of PFD, Ethyl cellulose (EC 300) with …
the preparation of sustained release microparticles of PFD, Ethyl cellulose (EC 300) with …
Progress and prospect of hydrate-based desalination technology
With the continuous growth of the population and the improvement of production, the
shortage of freshwater has plagued many countries. The use of novel technologies such as …
shortage of freshwater has plagued many countries. The use of novel technologies such as …