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[HTML][HTML] Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19
Coronavirus disease 2019 is a newly emerging infectious disease currently spreading
across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome …
across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome …
COVID-19: drug targets and potential treatments
C Gil, T Ginex, I Maestro, V Nozal… - Journal of medicinal …, 2020 - ACS Publications
Currently, humans are immersed in a pandemic caused by the emerging severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health …
respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health …
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
X Ou, Y Liu, X Lei, P Li, D Mi, L Ren, L Guo… - Nature …, 2020 - nature.com
Abstract Since 2002, beta coronaviruses (CoV) have caused three zoonotic outbreaks,
SARS-CoV in 2002–2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late …
SARS-CoV in 2002–2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late …
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019
has triggered an ongoing global pandemic of the severe pneumonia-like disease …
has triggered an ongoing global pandemic of the severe pneumonia-like disease …
Beyond PI3Ks: targeting phosphoinositide kinases in disease
JE Burke, J Triscott, BM Emerling… - Nature Reviews Drug …, 2023 - nature.com
Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …
Oral antiviral treatments for COVID-19: opportunities and challenges
L Rahmah, SO Abarikwu, AG Arero, M Essouma… - Pharmacological …, 2022 - Springer
The use of antiviral COVID-19 medications can successfully inhibit SARS-CoV-2 replication
and prevent disease progression to a more severe form. However, the timing of antiviral …
and prevent disease progression to a more severe form. However, the timing of antiviral …
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
Virus entry is a multistep process. It initiates when the virus attaches to the host cell and
ends when the viral contents reach the cytosol. Genetically unrelated viruses can subvert …
ends when the viral contents reach the cytosol. Genetically unrelated viruses can subvert …
Roles of PIKfyve in multiple cellular pathways
P Rivero-Ríos, LS Weisman - Current Opinion in Cell Biology, 2022 - Elsevier
Phosphoinositide signaling lipids are crucial for eukaryotes and regulate many aspects of
cell function. These signaling molecules are difficult to study because they are extremely low …
cell function. These signaling molecules are difficult to study because they are extremely low …
Therapeutic strategies to target the Ebola virus life cycle
Following the Ebola virus disease epidemic in west Africa, there has been increased
awareness of the need for improved therapies for emerging diseases, including viral …
awareness of the need for improved therapies for emerging diseases, including viral …
Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions
A Goc, W Sumera, M Rath, A Niedzwiecki - PLoS One, 2021 - journals.plos.org
In the pursuit of suitable and effective solutions to SARS-CoV-2 infection, we investigated
the efficacy of several phenolic compounds in controlling key cellular mechanisms involved …
the efficacy of several phenolic compounds in controlling key cellular mechanisms involved …