Caenorhabditis elegans survives on ephemeral food sources in the wild, and the species
has a variety of adaptive responses to starvation. These features of its life history make the …

Response and adaptation to stress are critical for the survival of all living organisms. The
regulation of the transcriptional machinery is an important aspect of these complex …

Gene activity defines cell identity, drives intercellular communication, and underlies the
functioning of multicellular organisms. We present the single-cell resolution atlas of gene …

Chromatin architecture is a fundamental mediator of genome function. Fasting is a major
environmental cue across the animal kingdom, yet how it impacts three-dimensional (3D) …

Antibiotic contaminants could promote the formation of harmful cyanobacterial blooms
through hormetic stimulation, but the mechanisms underlying these stimulatory effects …

Omics tools provide broad datasets for biological discovery. However, the computational
tools for identifying important genes or pathways in RNA-seq, proteomics, or GWAS …

Animals must weigh competing needs and states to generate adaptive behavioral
responses to the environment. Sensorimotor circuits are thus tasked with integrating diverse …

Dietary restriction (DR) interventions have demonstrated their efficacy in extending lifespan;
however, the association between lifespan extension and health span remains unclear. This …

Key discoveries in aging research have been made possible with the use of model
organisms. Caenorhabditis elegans is a short-lived nematode that has become a well …

In human neurodegenerative diseases, neurons can transfer toxic protein aggregates to
surrounding cells, promoting pathology via poorly understood mechanisms. In …