Mammalian mitochondrial DNA (mtDNA) is replicated and transcribed by phage-like DNA
and RNA polymerases, and our understanding of these processes has progressed …

The mitochondrial genome encodes core subunits of the respiratory chain that drives
oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in …

The expression of mitochondrial genes is regulated in response to the metabolic needs of
different cell types, but the basic mechanisms underlying this process are still poorly …

Mitochondria are the major source of ATP in the cell. Five multi-subunit complexes in the
inner membrane of the organelle are involved in the oxidative phosphorylation required for …

Mammalian mitochondrial DNA (mtDNA) encodes 13 proteins that are essential for the
function of the oxidative phosphorylation system, which is composed of four respiratory …

Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA
genome and a dedicated DNA replication machinery is required for its maintenance. Many …

Cytoplasmic RNA granules play a central role in mRNA metabolism, but the importance of
mitochondrial RNA granules remains relatively unexplored. We characterized their …

Mitochondria have multiple functions, including synthesis of adenine triphosphate,
production of reactive oxygen species, calcium signalling, thermogenesis and apoptosis …

Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the
accurate replication, transmission and preservation of its integrity throughout the life of the …

The bacterial heritage of mitochondria, as well as its independent genome [mitochondrial
DNA (mtDNA)] and polycistronic transcripts, led to the view that mitochondrial transcriptional …