WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Early stages of vascular development include endothelial cell differentiation in a network of
arteries, veins, and lymphatics. Subsequently, to respond to the specific needs of the organs …

Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the
further expansion of (pre-) malignant cells,. Key signalling components of the senescence …

Glioblastoma stem cells (GSCs) are implicated in tumor neovascularization, invasiveness,
and therapeutic resistance. To illuminate mechanisms governing these hallmark features …

Recently, various approaches for controlling the embryonic stem (ES) cell microenvironment
have been developed for regulating cellular fate decisions. It has been reported that the …

Rheumatoid arthritis (RA) is a chronic symmetrical autoimmune disease of unknown etiology
that affects primarily the diarthrodial joints. Characteristic features of RA pathogenesis are …

Wnt signaling has been implicated in certain inflammatory diseases. However, the biological
role in the inflammatory regulation remains to be characterized. We investigated the …

The development of the vascular system requires orchestrated activities of various molecular
pathways to assure the formation of a hierarchically branched tubular network. Furthermore …

Solid tumour growth is dependent on the development of an adequate blood supply. For
years, sprouting angiogenesis has been considered an exclusive mechanism of tumour …

Disruption of adherens junctions between endothelial cells results in compromised
endothelial barrier function and in altered angiogenesis. Nitric oxide (NO) produced by …