Pseudomonas aeruginosa is the most prevalent pathogen of cystic fibrosis (CF) lung
disease. Its long persistence in CF airways is associated with sophisticated mechanisms of …

The long-term persistance of P. aeruginosa in the cystic fibrosis (CF) lung is characterized
by the selection of a variety of genotypes and phenotypes that typically descend from one …

Acute infections caused by pathogenic bacteria have been studied extensively for well over
100 years. These infections killed millions of people in previous centuries, but they have …

The bacterium Pseudomonas aeruginosa is especially pathogenic, often being associated
with intractable pneumonia and high mortality. How P. aeruginosa avoids immune clearance …

In individuals with polymicrobial infections, microbes often display synergistic interactions
that can enhance their colonization, virulence, or persistence. One of the most prevalent …

Between 1 and 2% of the population in the developed world experiences a nonhealing or
chronic wound characterized by an apparent arrest in a stage dominated by inflammatory …

The ability of Pseudomonas aeruginosa to form biofilms and cause chronic infections in the
lungs of cystic fibrosis patients is well documented. Numerous studies have revealed that P …

While complex intra-and interspecies microbial community dynamics are apparent during
chronic infections and likely alter patient health outcomes, our understanding of these …

Antimicrobial peptides (APs) are important host weapons against infections. Nearly all APs
are cationic and their microbicidal action is initiated through interactions with the anionic …

Cystic fibrosis is a lethal autosomal recessive condition caused by a defect of the
transmembrane conductance regulator gene that has a key role in cell homeostasis. A …