Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

Cancer and stem cells appear to share a common metabolic profile that is characterized by
high utilization of glucose through aerobic glycolysis. In the presence of sufficient nutrients …

Permanent residency in the eukaryotic cell pressured the prokaryotic mitochondrial ancestor
to strategize for intracellular living. Mitochondria are able to autonomously integrate and …

Mitochondrial dysfunction is a hallmark of many diseases. The retrograde signaling initiated
by dysfunctional mitochondria can bring about global changes in gene expression that alters …

The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …

In the past mitochondria were considered as the “powerhouse” of cell, since they generate
more than 90% of ATP in aerobic conditions through the oxidative phosphorylation …

Current research has demonstrated that mitochondrial morphology, distribution, and function
are maintained by the balanced regulation of mitochondrial fission and fusion, and …

Highlights•The interplay of regulators of mitophagy, mitochondrial dynamics, and apoptosis
controls cell fate.•Mitochondrial dynamics impacts transformation, stemness, and cancer cell …

Metabolism describes the life-sustaining chemical reactions in organisms that provide both
energy and building blocks for cellular survival and proliferation. Dysregulated metabolism …

Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria
are essential organelles responsible for numerous physiologic processes, such as energy …