The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters
MD Parker, WF Boron - Physiological reviews, 2013 - journals.physiology.org
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
Intracellular pH regulation by acid-base transporters in mammalian neurons
Intracellular pH (pHi) regulation in the brain is important in both physiological and
physiopathological conditions because changes in pHi generally result in altered neuronal …
physiopathological conditions because changes in pHi generally result in altered neuronal …
Modular structure of sodium-coupled bicarbonate transporters
Mammalian genomes contain 10 SLC4 genes that, between them, encode three Cl–HCO3
exchangers, five Na+-coupled HCO3 transporters (NCBTs), one reported borate transporter …
exchangers, five Na+-coupled HCO3 transporters (NCBTs), one reported borate transporter …
Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl–self-exchange activity
The SLC4A10 gene product, commonly known as NCBE, is highly expressed in rodent brain
and has been characterized by others as a Na+-driven Cl-HCO 3 exchanger. However …
and has been characterized by others as a Na+-driven Cl-HCO 3 exchanger. However …
Structure and Function of SLC4 Family Transporters
Y Liu, J Yang, LM Chen - Frontiers in physiology, 2015 - frontiersin.org
The solute carrier SLC4 family consists of 10 members, nine of which are HCO 3-
transporters, including three Na+-independent Cl−/HCO 3-exchangers AE1, AE2, and AE3 …
transporters, including three Na+-independent Cl−/HCO 3-exchangers AE1, AE2, and AE3 …
Distinguishing among HCO3−, CO3=, and H+ as substrates of proteins that appear to be “bicarbonate” transporters
Background Differentiating among HCO 3−, CO 3=, and H+ movements across membranes
has long seemed impossible. We now seek to discriminate unambiguously among three …
has long seemed impossible. We now seek to discriminate unambiguously among three …
Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)
The choroid plexus lining the four ventricles in the brain is where the majority of
cerebrospinal fluid (CSF) is produced. The secretory function of the choroid plexus is …
cerebrospinal fluid (CSF) is produced. The secretory function of the choroid plexus is …
A SLC4-like anion exchanger from renal tubules of the mosquito (Aedes aegypti): evidence for a novel role of stellate cells in diuretic fluid secretion
Transepithelial fluid secretion across the renal (Malpighian) tubule epithelium of the
mosquito (Aedes aegypti) is energized by the vacuolar-type (V-type) H+-ATPase and not the …
mosquito (Aedes aegypti) is energized by the vacuolar-type (V-type) H+-ATPase and not the …
Na+/HCO3–Cotransporter NBCn2 Mediates HCO3− Reclamation in the Apical Membrane of Renal Proximal Tubules
YM Guo, Y Liu, M Liu, JL Wang, ZD **e… - Journal of the …, 2017 - journals.lww.com
The kidney maintains systemic acid-base balance by reclaiming from the renal tubule lumen
virtually all HCO 3− filtered in glomeruli and by secreting additional H+ to titrate luminal …
virtually all HCO 3− filtered in glomeruli and by secreting additional H+ to titrate luminal …
Expression and localization of Na-driven Cl-HCO3− exchanger (SLC4A8) in rodent CNS
The Na+-driven Cl-HCO3 exchanger (NDCBE or SLC4A8) is a member of the solute carrier
4 (SLC4) family of HCO3− transporters, which includes products of 10 genes with similar …
4 (SLC4) family of HCO3− transporters, which includes products of 10 genes with similar …