Despite extensive global efforts in the fight against killer infectious diseases, they still cause
one in four deaths worldwide and are important causes of long-term functional disability …

One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

Pharmacologically-induced activation of replication competent proviruses from latency in the
presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV …

Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+
T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important …

Highly active antiretroviral therapy (HAART) suppresses HIV-1 replication but cannot
eliminate the virus because HIV-1 establishes latent infection. Interruption of HAART leads …

HIV-1 can establish a state of latent infection at the level of individual T cells. Latently
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …

This Perspective proposes definitions for key terms in the field of HIV-1 latency and
eradication. In the context of eradication, a reservoir is a cell type that allows persistence of …

Zinc binding groups (ZBGs) play a crucial role in targeting histone deacetylase inhibitors
(HDACIs) to the active site of histone deacetylases (HDACs), thus determining the potency …

The HIV-1 pandemic is a complex mix of diverse epidemics within and between countries
and regions of the world, and is undoubtedly the defining public-health crisis of our time …

BACKGROUND A central challenge to emerging efforts to cure HIV infection is the
persistence of quiescent but replication-competent proviral genomes in resting CD4+ T …