Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Breast cancer (BC) is a prevalent malignant tumor in women, and its incidence has been
steadily increasing in recent years. Compared with other types of cancer, it has the highest …

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related
death in the United States. Despite the high prevalence of Kras mutations in pancreatic …

The renewal of lung epithelial cells is normally slow unless the lung is injured. The resident
epithelial stem cells rapidly proliferate and differentiate to maintain lung structure and …

Abstract Background Ginsenoside Rh2 (G‐Rh2) exerts anti‐tumor activity in non‐small cell
lung cancer (NSCLC). microRNAs (miRNAs, miRs) play pivotal roles in NSCLC. We aimed …

Mammalian STE20-like protein kinases (MST), including MST1, MST2, MST3, and MST4,
belong to the germinal center kinase (GCK) family. Kinase MST1/2 is an important …

Small guanosine triphosphatases (GTPases) of the RAS superfamily signal by directly
binding to multiple downstream effector proteins. Effectors are defined by a folded RAS …

The Hippo pathway controls several biological processes, including cell growth,
differentiation, motility, stemness, cell contact, immune cell maturation, organ size, and …

Background Currently, the identification of accurate biomarkers for the diagnosis of patients
with early-stage lung cancer remains difficult. Fortunately, metabolomics technology can be …

Simple Summary UM-164, as a high-potency c-Src inhibitor, is the original lead compound
to be developed for targeting triple-negative breast cancer. Here we validated the fact that …