Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral …

Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis
leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the …

In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked
during bone growth and regeneration in bone modeling and during bone homeostasis in …

Osteoarthritis is a degenerative disorder that can severely affect joints, and new treatment
strategies are urgently needed. Administration of mesenchymal stem cell (MSC)‐derived …

Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …

Osteoarthritis (OA), one of the most common joint diseases, is characterized by fibrosis,
rhagadia, ulcers and attrition of articular cartilage due to a number of factors. The etiology of …

OA is now well accepted as a low-grade inflammatory disease affecting the whole joint. In
addition to mechanical loading, inflammation (particularly synovitis), contributes significantly …

Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …

Exosomes participate in many physiological and pathological processes by regulating cell–
cell communication, which are involved in numerous diseases, including osteoarthritis (OA) …