Self-assembly of stabilized droplets from liquid–liquid phase separation for higher-order structures and functions

M Naz, L Zhang, C Chen, S Yang, H Dou… - Communications …, 2024 - nature.com
Dynamic microscale droplets produced by liquid–liquid phase separation (LLPS) have
emerged as appealing biomaterials due to their remarkable features. However, the …

Exploring giant unilamellar vesicle production for artificial cells—current challenges and future directions

L Van de Cauter, L van Buren, GH Koenderink… - Small …, 2023 - Wiley Online Library
Creating an artificial cell from the bottom up is a long‐standing challenge and, while
significant progress has been made, the full realization of this goal remains elusive …

Biomimetic behaviors in hydrogel artificial cells through embedded organelles

ME Allen, JW Hindley, N O'Toole, HS Cooke… - Proceedings of the …, 2023 - pnas.org
Artificial cells are biomimetic structures formed from molecular building blocks that replicate
biological processes, behaviors, and architectures. Of these building blocks, hydrogels have …

Magnetic modulation of biochemical synthesis in synthetic cells

KK Zhu, I Gispert Contamina, O Ces… - Journal of the …, 2024 - ACS Publications
Synthetic cells can be constructed from diverse molecular components, without the design
constraints associated with modifying'living'biological systems. This can be exploited to …

Lipid vesicle-based molecular robots

Z Peng, S Iwabuchi, K Izumi, S Takiguchi, M Yamaji… - Lab on a Chip, 2024 - pubs.rsc.org
A molecular robot, which is a system comprised of one or more molecular machines and
computers, can execute sophisticated tasks in many fields that span from nanomedicine to …

Physically and Chemically Compartmentalized Polymersomes for Programmed Delivery and Biological Applications

Y Gao, C Gao, Y Fan, H Sun, J Du - Biomacromolecules, 2023 - ACS Publications
Multicompartment polymersomes (MCPs) refer to polymersomes that not only contain one
single compartment, either in the membrane or in the internal cavity, but also mimic the …

Engineering a nanoscale liposome-in-liposome for in situ biochemical synthesis and multi-stage release

CP Pilkington, I Gispert, SY Chui, JM Seddon… - Nature Chemistry, 2024 - nature.com
Soft-matter nanoscale assemblies such as liposomes and lipid nanoparticles have the
potential to deliver and release multiple cargos in an externally stimulated and site-specific …

Nucleated synthetic cells with genetically driven intercompartment communication

IA Ioannou, C Monck, F Ceroni, NJ Brooks… - Proceedings of the …, 2024 - pnas.org
Eukaryotic cells are characterized by multiple chemically distinct compartments, one of the
most notable being the nucleus. Within these compartments, there is a continuous exchange …

Atypical artificial cells: Novel biomimetic materials for combating cancer

Z Ren, Q Wan, Y Zhu, L Li, K Wang… - Interdisciplinary …, 2024 - Wiley Online Library
The functional concept of using synthetic entities to supplement or replace certain functions
or structures of biological cells is realized by the development of atypical artificial cells using …

Recent advances of droplet-based microfluidics for engineering artificial cells

S Fasciano, S Wang - SLAS technology, 2024 - Elsevier
Artificial cells, synthetic cells, or minimal cells are microengineered cell-like structures that
mimic the biological functions of cells. Artificial cells are typically biological or polymeric …