UVB-induced microvesicle particle release and its effects on the cutaneous microenvironment

TC Frommeyer, MM Gilbert, GV Brittain, T Wu… - Frontiers in …, 2022 - frontiersin.org
Ultraviolet B radiation (UVB) has profound effects on human skin that results in a broad
spectrum of immunological local and systemic responses and is the major cause of skin …

Progress in the development of platelet‐activating factor receptor (PAFr) antagonists and applications in the treatment of inflammatory diseases

IK Hyland, RF O'Toole, JA Smith… - ChemMedChem, 2018 - Wiley Online Library
Platelet‐activating factor (PAF) and its receptor (PAFr) have been implicated in a wide range
of diseases and disorders that originate from the activation of inflammatory pathways …

A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome

MB Casaro, AM Thomas, E Mendes, C Fukumori… - Microbiome, 2021 - Springer
The phenotypes of allergic airway diseases are influenced by the interplay between host
genetics and the gut microbiota, which may be modulated by probiotics. We investigated the …

Endangered lymphocytes: The effects of alloxan and streptozotocin on immune cells in type 1 induced diabetes

LAD Queiroz, JB Assis, JPT Guimarães… - Mediators of …, 2021 - Wiley Online Library
Alloxan (ALX) and streptozotocin (STZ) are extensively used to induce type 1 diabetes (T1D)
in animal models. This study is aimed at evaluating the differences in immune parameters …

Naja annulifera Snake: New insights into the venom components and pathogenesis of envenomation

F Silva-de-Franca, IM Villas-Boas… - PLoS Neglected …, 2019 - journals.plos.org
Background Naja annulifera is a medically important venomous snake occurring in some of
the countries in Sub-Saharan Africa. Accidental bites result in severe coagulation …

Experimental allergic airway inflammation impacts gut homeostasis in mice

CM Nascimento, MC Casaro, ER Perez, WR Ribeiro… - Heliyon, 2023 - cell.com
Abstract Background/Aims: Epidemiological data show that there is an important relationship
between respiratory and intestinal diseases. To improve our understanding on the …

[HTML][HTML] Platelet activating factor receptor antagonists improve the efficacy of experimental chemo-and radiotherapy

IA da Silva Junior, LN de Sousa Andrade, S Jancar… - Clinics, 2018 - SciELO Brasil
Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has
emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific …

Dendritic cells expressing MyD88 molecule are necessary and sufficient for CpG-mediated inhibition of IgE production in vivo

RW Alberca Custodio, L Mirotti, E Gomes, FPB Nunes… - Cells, 2019 - mdpi.com
Elevated levels of immunoglobulin E (IgE) are associated with allergies and other
immunological disorders. Sensitization with alum adjuvant favours IgE production while CpG …

Leukotriene B4 modulation of murine dendritic cells affects adaptive immunity

MA Pires-Lapa, MM Koga, IA da Silva Jr… - Prostaglandins & Other …, 2019 - Elsevier
Dendritic cells (DCs) link innate and adaptive immunity. The microenvironment generated
during the innate immunity affects DCs and the type of adaptive immunity generated. Lipid …

Maternal supplementation with a synbiotic has distinct outcomes on offspring gut microbiota formation in A/J and C57BL/6 mice, differentially affecting airway …

C Fukumori, MB Casaro, AM Thomas, E Mendes… - Journal of Functional …, 2019 - Elsevier
Emerging evidence has shown that the maternal diet influences the microbiota. Our
objective was to elucidate whether synbiotic consumption during the perinatal period …