The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

J Zeng, T Bao, K Yang, X Zhu, S Wang… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

Recent advances of traditional Chinese medicine for the prevention and treatment of atherosclerosis

W Zhi, Y Liu, X Wang, H Zhang - Journal of Ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance Atherosclerosis (AS) is a common systemic disease with
increasing morbidity and mortality worldwide. Traditional Chinese medicine (TCM) with …

Paeonol Protects Against Methotrexate-Induced Nephrotoxicity via Upregulation of P-gp Expression and Inhibition of TLR4/NF-κB Pathway

MA Morsy, AAK El-Sheikh, SMN Abdel-Hafez… - Frontiers in …, 2022 - frontiersin.org
Methotrexate (MTX) is a well-known anticancer drug that causes nephrotoxicity as a side
effect. To investigate the mechanisms by which paeonol, a natural phenolic compound, can …

Investigation on the inhibition mechanism and binding behavior of paeonol to tyrosinase and its anti-browning property by multi-spectroscopic and molecular docking …

X Min, L Lu, X Xu, Y Wen, X Zheng - International Journal of Biological …, 2023 - Elsevier
Paeonol, as one effective tyrosinase inhibitor, had been used as food preservative and
clinical medication for skin disorders. In this study, the inhibition mechanism and binding …

Paeonol ameliorates endometrial hyperplasia in mice via inhibiting PI3K/AKT pathway-related ferroptosis

S Liu, X Cao, T Zhang, C Zhang, J Qu, Y Sun, W Lv… - Phytomedicine, 2023 - Elsevier
Abstract Background Paeonol (Pae) is one of the active ingredients from components of
Guizhi Fuling Capsule, a traditional Chinese medicine widely used for the treatment of …

Natural products as the calcium channel blockers for the treatment of arrhythmia: Advance and prospect

L **ao, XJ Chen, JK Feng, WN Li, S Yuan, Y Hu - Fitoterapia, 2023 - Elsevier
Arrhythmia is one of the commonly heart diseases with observed abnormal heart-beat
rhythm that caused by the obstacles of cardiac activity and conduction. The arrhythmic …

Review of the protective mechanism of Paeonol on cardiovascular disease

C Yang, J Cheng, Q Zhu, Q Pan, K Ji… - … Design, Development and …, 2023 - Taylor & Francis
Cardiovascular disease (CVD) is one of the leading causes of death in the world. Paeonol
(Pae) is a phenolic component extracted from peony bark, peony root and Xu Changqing …

[HTML][HTML] Antifungal and Antibiofilm Efficacy of Paeonol Treatment Against Biofilms Comprising Candida albicans and/or Cryptococcus neoformans

W Qian, X Li, Q Liu, J Lu, T Wang… - Frontiers in Cellular and …, 2022 - frontiersin.org
Fungal populations are commonly found in natural environments and present enormous
health care challenges, due to increased resistance to antifungal agents. Paeonol exhibits …

Advances in immunosuppressive agents based on signal pathway

Z Xu, M Chu - Frontiers in Pharmacology, 2022 - frontiersin.org
Immune abnormality involves in various diseases, such as infection, allergic diseases,
autoimmune diseases, as well as transplantation. Several signal pathways have been …

Quality evaluation of traditional chinese medicine prescription in naolingsu capsule based on combinative method of fingerprint, quantitative determination, and …

L Xu, Y Jiao, W Cui, B Wang, D Guo… - Journal of Analytical …, 2022 - Wiley Online Library
Background. Naolingsu capsule (NLSC) is a well‐known traditional Chinese medicine
(TCM) prescription in China. It is widely used to treat neurasthenia, insomnia, cardiovascular …