Efficient and feasible biocatalysts: Strategies for enzyme improvement. A review

SH Albayati, NG Nezhad, AG Taki… - International Journal of …, 2024 - Elsevier
Owing to the environmental friendliness and vast advantages that enzymes offer in the
biotechnology and industry fields, biocatalysts are a prolific investigation field. However, the …

Artificial Intelligence Methods and Models for Retro-Biosynthesis: A Sco** Review

G Gricourt, P Meyer, T Duigou, JL Faulon - ACS Synthetic Biology, 2024 - ACS Publications
Retrosynthesis aims to efficiently plan the synthesis of desirable chemicals by strategically
breaking down molecules into readily available building block compounds. Having a long …

Artificial intelligence aided lipase production and engineering for enzymatic performance improvement

F Ge, G Chen, M Qian, C Xu, J Liu, J Cao… - Journal of Agricultural …, 2023 - ACS Publications
With the development of artificial intelligence (AI), tailoring methods for enzyme engineering
have been widely expanded. Additional protocols based on optimized network models have …

Recent advances in structure‐based enzyme engineering for functional reconstruction

SY Xu, L Zhou, Y Xu, HY Hong, C Dai… - Biotechnology and …, 2023 - Wiley Online Library
Structural information can help engineer enzymes. Usually, specific amino acids in particular
regions are targeted for functional reconstruction to enhance the catalytic performance …

[HTML][HTML] Engineering and expression strategies for optimization of L-asparaginase development and production

AN Shishparenok, YA Gladilina… - International Journal of …, 2023 - mdpi.com
Genetic engineering for heterologous expression has advanced in recent years. Model
systems such as Escherichia coli, Bacillus subtilis and Pichia pastoris are often used as host …

Progress and prospects of natural glycoside sweetener biosynthesis: A review

G Qu, Y Liu, Q Ma, J Li, G Du, L Liu… - Journal of Agricultural and …, 2023 - ACS Publications
To achieve an adequate sense of sweetness with a healthy low-sugar diet, it is necessary to
explore and produce sugar alternatives. Recently, glycoside sweeteners and their …

Computer-Aided Semi-Rational Design to Enhance the Activity of l-Sorbosone Dehydrogenase from Gluconobacter oxidans WSH-004

D Li, X Wang, L Huo, W Zeng, J Li… - Journal of Agricultural …, 2024 - ACS Publications
The titer of the microbial fermentation products can be increased by enzyme engineering. l-
Sorbosone dehydrogenase (SNDH) is a key enzyme in the production of 2-keto-l-gulonic …

[HTML][HTML] Adapting enzymes to improve their functionality in plants: why and how

ER Oliveira-Filho, C Voiniciuc… - Biochemical Society …, 2023 - portlandpress.com
Synthetic biology creates new metabolic processes and improves existing ones using
engineered or natural enzymes. These enzymes are often sourced from cells that differ from …

Advances in recombinant protease production: current state and perspectives

X Liu, M Lian, M Zhao, M Huang - World Journal of Microbiology and …, 2024 - Springer
Proteases, enzymes that catalyze the hydrolysis of peptide bonds in proteins, are important
in the food industry, biotechnology, and medical fields. With increasing demand for …

[HTML][HTML] Microbial β-glucosidases: Recent advances and applications

B Magwaza, A Amobonye, S Pillai - Biochimie, 2024 - Elsevier
The global β-glucosidase market is currently estimated at∼ 400 million USD, and it is
expected to double in the next six years; a trend that is mainly ascribed to the demand for the …