Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Reinforcement learning in healthcare: A survey

C Yu, J Liu, S Nemati, G Yin - ACM Computing Surveys (CSUR), 2021 - dl.acm.org
As a subfield of machine learning, reinforcement learning (RL) aims at optimizing decision
making by using interaction samples of an agent with its environment and the potentially …

[HTML][HTML] Half a century of research on antipsychotics and schizophrenia: A scientometric study of hotspots, nodes, bursts, and trends

M Sabe, T Pillinger, S Kaiser, C Chen, H Taipale… - Neuroscience & …, 2022 - Elsevier
Abstract Changes over 50 years of research on antipsychotics in schizophrenia have
occurred. A scientometric synthesis of such changes over time and a measure of …

European Psychiatric Association guidance on assessment of cognitive impairment in schizophrenia

A Vita, W Gaebel, A Mucci, G Sachs, A Erfurth… - European …, 2022 - cambridge.org
Background Impairment in a wide range of cognitive abilities has been consistently reported
in individuals with schizophrenia. Both neurocognitive and social cognitive deficits are …

Cognitive deficits in psychotic disorders: a lifespan perspective

JM Sheffield, NR Karcher, DM Barch - Neuropsychology review, 2018 - Springer
Individuals with disorders that include psychotic symptoms (ie psychotic disorders)
experience broad cognitive impairments in the chronic state, indicating a dimension of …

Effectiveness of KarXT (xanomeline-trospium) for cognitive impairment in schizophrenia: post hoc analyses from a randomised, double-blind, placebo-controlled …

C Sauder, LA Allen, E Baker, AC Miller, SM Paul… - Translational …, 2022 - nature.com
The muscarinic receptor agonist xanomeline improved cognition in phase 2 trials in
Alzheimer's disease and schizophrenia. We present data on the effect of KarXT (xanomeline …

Antipsychotics: mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology

SJ Kaar, S Natesan, R Mccutcheon, OD Howes - Neuropharmacology, 2020 - Elsevier
Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

A non–D2-receptor-binding drug for the treatment of schizophrenia

KS Koblan, J Kent, SC Hopkins… - … England Journal of …, 2020 - Mass Medical Soc
Background An oral compound, SEP-363856, that does not act on dopamine D2 receptors
but has agonist activity at trace amine–associated receptor 1 (TAAR1) and 5 …

Schizophrenia: overview and treatment options

KR Patel, J Cherian, K Gohil… - Pharmacy and …, 2014 - pmc.ncbi.nlm.nih.gov
Schizophrenia: Overview and Treatment Options - PMC Skip to main content Here's how you
know Official websites use .gov A .gov website belongs to an official government organization …

Cognitive impairment in psychotic illness: prevalence, profile of impairment, developmental course, and treatment considerations

A McCleery, KH Nuechterlein - Dialogues in clinical neuroscience, 2019 - Taylor & Francis
Despite effective pharmacological treatments for psychotic symptoms (eg, hallucinations,
delusions), functional outcomes for people with psychotic disorders are often disappointing …