Mouse models of glioblastoma for the evaluation of novel therapeutic strategies
Glioblastoma (GBM) is an incurable brain tumor with a median survival of approximately 15
months despite an aggressive standard of care that includes surgery, chemotherapy, and …
months despite an aggressive standard of care that includes surgery, chemotherapy, and …
CXCL1: Gene, Promoter, Regulation of Expression, mRNA Stability, Regulation of Activity in the Intercellular Space
J Korbecki, K Barczak, I Gutowska, D Chlubek… - International journal of …, 2022 - mdpi.com
CXCL1 is one of the most important chemokines, part of a group of chemotactic cytokines
involved in the development of many inflammatory diseases. It activates CXCR2 and, at high …
involved in the development of many inflammatory diseases. It activates CXCR2 and, at high …
AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma
A causative understanding of genetic factors that regulate glioblastoma pathogenesis is of
central importance. Here we developed an adeno-associated virus–mediated …
central importance. Here we developed an adeno-associated virus–mediated …
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma
The majority of glioblastomas can be classified into molecular subgroups based on
mutations in the TERT promoter (TERTp) and isocitrate dehydrogenase 1 or 2 (IDH). These …
mutations in the TERT promoter (TERTp) and isocitrate dehydrogenase 1 or 2 (IDH). These …
[HTML][HTML] Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma …
S Hong, JY You, K Paek, J Park, SJ Kang, EH Han… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Glioblastoma (GBM) is one of the most aggressive types of brain cancer. GBM
progression is closely associated with microglia activation; therefore, understanding the …
progression is closely associated with microglia activation; therefore, understanding the …
ADAR-mediated RNA editing predicts progression and prognosis of gastric cancer
Backgroud & Aims Gastric cancer (GC) is the third leading cause of global cancer mortality.
Adenosine-to-inosine RNA editing is a recently described novel epigenetic mechanism …
Adenosine-to-inosine RNA editing is a recently described novel epigenetic mechanism …
High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma
Y Yoshikawa, M Emi… - Proceedings of the …, 2016 - National Acad Sciences
We used a custom-made comparative genomic hybridization array (aCGH; average probe
interval 254 bp) to screen 33 malignant mesothelioma (MM) biopsies for somatic copy …
interval 254 bp) to screen 33 malignant mesothelioma (MM) biopsies for somatic copy …
In vitro and in vivo enhancement of temozolomide effect in human glioblastoma by non-invasive application of cold atmospheric plasma
Simple Summary Glioblastoma (GBM) is an aggressive type of brain cancer, with which only
25% of patients survive for more than one year. Treatment of GBM has remained a …
25% of patients survive for more than one year. Treatment of GBM has remained a …
Genomic and molecular landscape of homologous recombination deficiency across multiple cancer types
Z Shi, B Chen, X Han, W Gu, S Liang, L Wu - Scientific Reports, 2023 - nature.com
Homologous recombination deficiency (HRD) causes faulty double-strand break repair and
is a prevalent cause of tumorigenesis. However, the incidence of HRD and its clinical …
is a prevalent cause of tumorigenesis. However, the incidence of HRD and its clinical …
Estradiol induces epithelial to mesenchymal transition of human glioblastoma cells
The mesenchymal phenotype of glioblastoma multiforme (GBM), the most frequent and
malignant brain tumor, is associated with the worst prognosis. The epithelial–mesenchymal …
malignant brain tumor, is associated with the worst prognosis. The epithelial–mesenchymal …