Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers
D Rong, G Sun, F Wu, Y Cheng, G Sun, W Jiang… - … Therapy-Nucleic Acids, 2021 - cell.com
As next-generation sequencing (NGS) is lea** forward, more than 160 covalent RNA
modification processes have been reported, and they are widely present in every organism …
modification processes have been reported, and they are widely present in every organism …
Evaluation of different computational methods on 5-methylcytosine sites identification
Methylcytosine (m5C) plays an extremely important role in the basic biochemical process.
With the great increase of identified m5C sites in a wide variety of organisms, their …
With the great increase of identified m5C sites in a wide variety of organisms, their …
iLearn: an integrated platform and meta-learner for feature engineering, machine-learning analysis and modeling of DNA, RNA and protein sequence data
With the explosive growth of biological sequences generated in the post-genomic era, one
of the most challenging problems in bioinformatics and computational biology is to …
of the most challenging problems in bioinformatics and computational biology is to …
Deepm5C: a deep-learning-based hybrid framework for identifying human RNA N5-methylcytosine sites using a stacking strategy
As one of the most prevalent post-transcriptional epigenetic modifications, N5-
methylcytosine (m5C) plays an essential role in various cellular processes and disease …
methylcytosine (m5C) plays an essential role in various cellular processes and disease …
SDM6A: a web-based integrative machine-learning framework for predicting 6mA sites in the rice genome
DNA N 6-adenine methylation (6mA) is an epigenetic modification in prokaryotes and
eukaryotes. Identifying 6mA sites in rice genome is important in rice epigenetics and …
eukaryotes. Identifying 6mA sites in rice genome is important in rice epigenetics and …
Prediction of bio-sequence modifications and the associations with diseases
C Ao, L Yu, Q Zou - Briefings in Functional Genomics, 2021 - academic.oup.com
Modifications of protein, RNA and DNA play an important role in many biological processes
and are related to some diseases. Therefore, accurate identification and comprehensive …
and are related to some diseases. Therefore, accurate identification and comprehensive …
Advances in mRNA 5-methylcytosine modifications: Detection, effectors, biological functions, and clinical relevance
G Guo, K Pan, S Fang, L Ye, X Tong, Z Wang… - … Therapy-Nucleic Acids, 2021 - cell.com
5-methylcytosine (m 5 C) post-transcriptional modifications affect the maturation, stability,
and translation of the mRNA molecule. These modifications play an important role in many …
and translation of the mRNA molecule. These modifications play an important role in many …
Novel insight into RNA modifications in tumor immunity: Promising targets to prevent tumor immune escape
An immunosuppressive state is a typical feature of the tumor microenvironment. Despite the
dramatic success of immune checkpoint inhibitor (ICI) therapy in preventing tumor cell …
dramatic success of immune checkpoint inhibitor (ICI) therapy in preventing tumor cell …
RF-PseU: a random forest predictor for RNA pseudouridine sites
One of the ubiquitous chemical modifications in RNA, pseudouridine modification is crucial
for various cellular biological and physiological processes. To gain more insight into the …
for various cellular biological and physiological processes. To gain more insight into the …
XGBoost framework with feature selection for the prediction of RNA N5-methylcytosine sites
5-methylcytosine (m5C) is indeed a critical post-transcriptional alteration that is widely
present in various kinds of RNAs and is crucial to the fundamental biological processes. By …
present in various kinds of RNAs and is crucial to the fundamental biological processes. By …