Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …

Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

Atherosclerosis, characterized by lipid‐rich plaques in the arterial wall, is an age‐related
disorder and a leading cause of mortality worldwide. However, the specific mechanisms …

Rapamycin was administered in food to genetically heterogeneous mice from the age of 9
months and produced significant increases in life span, including maximum life span, at …

Infusion of different hematopoietic stem cell populations and ex vivo expanded endothelial
progenitor cells augments neovascularization of tissue after ischemia and contributes to …

echocardiogram) may be expected to facilitate the identification of patients with chest pain of
an ischemic etiology (angina). In a patient presenting to the emergency department with …

The cellular and molecular processes that control vascular injury responses after
percutaneous coronary intervention involve a complex interplay among vascular cells and …

Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be
beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for …

Background Atherosclerosis is a chronic, systemic, and diffuse disease with focal
complications in different vascular beds. The mechanisms by which a specific site is …

Background—The maintenance of endothelial integrity plays a critical role in preventing
atherosclerotic disease progression. Endothelial progenitor cells (EPCs) were …