Cross-linking mass spectrometry for investigating protein conformations and protein–protein interactions─ a method for all seasons
Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …
Cross-linking mass spectrometry: methods and applications in structural, molecular and systems biology
Over the past decade, cross-linking mass spectrometry (CLMS) has developed into a robust
and flexible tool that provides medium-resolution structural information. CLMS data provide …
and flexible tool that provides medium-resolution structural information. CLMS data provide …
A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides
We describe pLink 2, a search engine with higher speed and reliability for proteome-scale
identification of cross-linked peptides. With a two-stage open search strategy facilitated by …
identification of cross-linked peptides. With a two-stage open search strategy facilitated by …
Cross-linking mass spectrometry (XL-MS): An emerging technology for interactomics and structural biology
Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …
and the assembly of multisubunit protein complexes that represent the functional …
Molecular damage in aging
Cellular metabolism and environmental interactions generate molecular damage affecting
all levels of biological organization. Accumulation of this damage over time is thought to …
all levels of biological organization. Accumulation of this damage over time is thought to …
Trans-proteomic pipeline: robust mass spectrometry-based proteomics data analysis suite
The Trans-Proteomic Pipeline (TPP) mass spectrometry data analysis suite has been in
continual development and refinement since its first tools, PeptideProphet and …
continual development and refinement since its first tools, PeptideProphet and …
A cross-linking/mass spectrometry workflow based on MS-cleavable cross-linkers and the MeroX software for studying protein structures and protein–protein …
Chemical cross-linking in combination with mass spectrometric analysis of the created cross-
linked products is an emerging technology aimed at deriving valuable structural information …
linked products is an emerging technology aimed at deriving valuable structural information …
Leveraging crosslinking mass spectrometry in structural and cell biology
Crosslinking mass spectrometry (crosslinking-MS) is a versatile tool providing structural
insights into protein conformation and protein-protein interactions. Its medium-resolution …
insights into protein conformation and protein-protein interactions. Its medium-resolution …
Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry
Mitochondrial protein interactions and complexes facilitate mitochondrial function. These
complexes range from simple dimers to the respirasome supercomplex consisting of …
complexes range from simple dimers to the respirasome supercomplex consisting of …
Computational methods for understanding mass spectrometry–based shotgun proteomics data
Computational proteomics is the data science concerned with the identification and
quantification of proteins from high-throughput data and the biological interpretation of their …
quantification of proteins from high-throughput data and the biological interpretation of their …