With the hope that disease-modifying treatments could target the molecular basis of
Parkinson's disease, even before the onset of symptoms, we propose a biologically based …

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …

With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …

The human transcriptome is composed of a vast RNA population that undergoes further
diversification by splicing. Detecting specific splice sites in this large sequence pool is the …

Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …

Clinical–pathological studies remain the gold‐standard for the diagnosis of Parkinson's
disease (PD). However, mounting data from genetic PD autopsies challenge the diagnosis …

Autosomal-recessive early-onset parkinsonism is clinically and genetically heterogeneous.
The genetic causes of approximately 50% of autosomal-recessive early-onset forms of …

Abstract In 1817, James Parkinson described the symptoms of the shaking palsy, a disease
that was subsequently defined in greater detail, and named after Parkinson, by Jean-Martin …

Almost two decades of genetic research in Parkinson's disease (PD) have remarkably
increased our knowledge regarding the genetic basis of PD with numerous genes and …